substance dependence/potassium

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Identification of selective agonists and antagonists to g protein-activated inwardly rectifying potassium channels: candidate medicines for drug dependence and pain.

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G protein-activated inwardly rectifying K(+) (GIRK) channels have been known to play a key role in the rewarding and analgesic effects of opioids. To identify potent agonists and antagonists to GIRK channels, we examined various compounds for their ability to activate or inhibit GIRK channels. A

[Clinical study of GIRK channel inhibitors as candidate medicines for drug dependence].

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Recently, topics related to substance dependence and behavioral addiction have been reported through the media. Therapeutic treatment for substance dependence and behavioral addiction is one of the challenges in a clinical practice. This is because there is no therapeutic treatment for a complete

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

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BACKGROUND We report a genome-wide association study (GWAS) of two populations, African-American and European-American (AA, EA) for opioid dependence (OD) in three sets of subjects, to identify pathways, genes, and alleles important in OD risk. METHODS The design employed three phases (on the basis

[Genetic polymorphisms commonly influencing efficacy of diverse addictive substances].

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Opioids, such as morphine and fentanyl, are widely used as effective analgesics for the treatment of acute and chronic pain. In addition, the opioid system has a key role in the rewarding effects of morphine, ethanol, cocaine and various other drugs. The authors have focused on G-protein-activated

Density and mineral content dynamics of bone tissue of the lower jaw of the rat on the background of opioid influence and after its withdrawal.

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Introduction: Over the past few years, the use of pharmaceuticals by the population, in particular, analgesics, has become widespread, and often their use is unreasonable from the medical point of view and leads to structural and functional changes in organs and systems of the body and

Development and validation of an HPLC method to determine the stability of fentanyl citrate and bupivacaine hydrochloride mixtures in infusion solutions.

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The use of a combination of different drugs in postoperative analgesia extends the time of analgesia, makes it more efficient and allows the use of lower drug doses, which leads to less risk of side effects and drug dependence. The aim of this study was to develop and validate an HPLC method to

[Genetic polymorphisms commonly associated with sensitivity to various addictive substances].

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