In 1529, Sudor anglicus, the 'English Sweating Sickness', spread from England to Germany reaching the city of Augsburg. Its exact nature is unclear: the symptoms were profuse sweating, uncontrollable thirst, and headaches, with death occurring within hours of infection. Those who survived the first
Natural and experimental cases of sweating sickness were treated using a hyperimmune serum as specific treatment and hyperimmune serum combined with symptomatic and supportive treatment based on the clinicopathological changes observed in cases of sweating sickness. The treatment regimens were found
Although of low morbidity, sweating sickness is readily induced in calves by infestation with positive Hyalomma truncatum adult ticks. This epitheliotrophic disease has no specific cure except by the administration of hyperimmune serum obtained from animals which have recovered and are subsequently
In 2001, spores of Bacillus anthracis were deliberately sent through the United States postal system, resulting in five deaths from inhalational anthrax. Rarely observed clinical symptoms associated with these cases led to a hypothesis about the etiology of the English Sweating Sickness. The disease
In this paper we aim to add additional knowledge regarding the occurrence, origin and epidemiological features of the English sweating sickness. The English sweating sickness raged in five devastating epidemics with mortality rates between 30 and 50% between 1485 and 1551 throughout England, and on
During the 15th and 16th centuries in England, there were five epidemics of a disease characterized by fever and profuse sweating and associated with high mortality. This disease became known as the English sweating sickness. The first epidemic occurred during 1485 at around the time of Henry
Experimentally-induced cases of sweating sickness in calves were used in an effort to correlate the blood chemistry with some of the known pathological changes. Results showed that the "sweating" associated with necrotic dermatitis did not alter blood electrolyte levels. Laboratory evidence of a
A Kenyan strain of Hyalomma truncatum was shown to cause sweating sickness in adult cattle in the laboratory. The typical lesions of moist eczema and mucous membrane changes were accompanied by a marked fall in circulating leucocytes with a severe neutropenia. Although all cattle recovered, some
Renaissance England witnessed a series of brief epidemics of a rapid and often fatal illness, the predominant feature of which was a disturbance of the autonomic nervous system. Profuse sweating was both an emblematic and ominous sign of this Sudor Anglicus. Its story is medically fascinating as
The English sweating sickness caused five devastating epidemics between 1485 and 1551, England was hit hardest, but on one occasion also mainland Europe, with mortality rates between 30% and 50%. The Picardy sweat emerged about 150 years after the English sweat disappeared, in 1718, in France. It
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