tabernaemontana crassa/leukemia

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Down-regulation of TNF-alpha receptors by conophylline in human T-cell leukemia cells.

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In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors, conophylline, a vinca alkaloid isolated from the plant Ervatamia microphylla, was found to inhibit TNF-alpha-induced NF-kappaB activation. We studied the effect of conophylline on TNF-alpha-induced

Growth inhibition of K-ras-expressing tumours by a new vinca alkaloid, conophylline, in nude mice.

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Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of 2-deoxyglucose in K-ras-NRK cells. Conophylline inhibited the growth of K-ras-NRK cells, but this inhibition was

Plant anticancer agents VI: Isolation of voacangine, voacamine, and epivoacorine from Tabernaemontana arborea sap.

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Fractionation of the sap of Tabernaemontana arborea, guided by cytotoxicity against the P-388 lymphocytic leukemia, yielded the known indole alkaloids voacangine, voacamine, and epivoacorine as the major cytotoxic constituents.

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