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tanshinone ii/breast neoplasms
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4 results
[A study on anticancer activity of tanshinone II A against human breast cancer].
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OBJECTIVE
To investigate the proliferation inhibition and apoptosis-associated genes expression of both human breast cancer cells with estrogen receptor (ER) positive and negative (MCF-7 and MDA-MB-231) which treated with tanshinone II A, and to elucidate its mechanism of activity.
METHODS
Human ER
[A study on the effect of Tanshinone II A against human breast cancer in vivo].
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OBJECTIVE
To confirm Tanshinone II A's (Tan II A) anti-cancer activity on nude mice bearing human breast cancer cells with estrogen receptor (ER) positive and negative and to elucidate the mechanism of its activity in vivo.
METHODS
Established the animal model of nude mices bearing human breast
Tanshinone II A improves the chemosensitivity of breast cancer cells to doxorubicin by inhibiting β-catenin nuclear translocation
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Numerous evidence link aberrant nuclear β-catenin accumulation to the development of breast cancer resistance, therefore, targeted inhibition of β-catenin nuclear translocation may effectively improve the chemosensitivity of breast cancer. Doxorubicin (Dox) is the most commonly used chemotherapeutic
Effect of tanshinone II on cell growth of breast cancer cell line type MCF-7 and MD-MB-231.
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Breast cancer is the most common form of cancer in women and the leading cause of cancer death in American women, with over 207,090 new cases of invasive breast cancer in women and about 39,840 deaths from breast cancer in 2010. Current therapies for breast cancer usually have variable effectiveness
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