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6 results
Cyclic sulfone derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to cyclic sulfone derivatives which are inhibitors a matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis, cancer,
Arylsulfonylamino hydroxamic acid derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to arylsulfonylamino hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of
Arylsulfonylamino hydroxamic acid derivatives
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The present invention relates to arylsulfonylamino hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue
Arylsulfonyl hydroxamic acid derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to arylsulfonyl hydroxamic acid derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of
(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides
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BACKGROUND OF THE INVENTION
The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment.
The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially
Phosphinate based inhibitors of matrix metalloproteases
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BACKGROUND OF THE INVENTION
The present invention relates to phosphinate based derivatives which are inhibitors of matrix metalloproteinases or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of a condition selected from the group consisting of arthritis,
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