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taxus canadensis/phenolic

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ArticlesClinical trialsPatents
2 results

Exogenous and endogenous increase in fungal GGPP increased fungal Taxol production.

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Taxol is an anticancer identified in both endophytic fungus and its host plant. Plant Taxol is a diterpenoid with geranylgeranyl diphosphate (GGPP) mediates the biosynthesis of its terpenoid moiety. Previous report has suggested that fungal Taxol may require terpenoid pathway for its biosynthesis.

Cell culture of Taxus as a source of the antineoplastic drug taxol and related taxanes.

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Callus cultures of Taxus cuspidata and Taxus canadensis were induced using different tissue explants including green and red arils, seed contents, young stems and needles. Callus derived from stem segments displayed the best growth in defined media. The culture medium was supplemented with reducing
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