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testosterone/sarcoma
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[Testosterone stimulation of the growth of a human osteogenic sarcoma strain transplanted into athymic rats].
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Intraperitoneal testosterone administration stimulated the growth of subcutaneously transplanted cell line of human osteogenic sarcoma in nude rats but did not provoke tumour metastasizing to other organs and tissues. The specific connection of androgens with receptor proteins in the cytosol
Lack of association of low testosterone with HIV-associated Kaposi's sarcoma.
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Ultrastructure of sarcoma 180 cells in mice treated with testosterone propionate.
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Effect of interferon alpha on high serum androgen concentrations in HIV positive men with Kaposi's sarcoma.
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OBJECTIVE
To measure serum androgen concentrations in men with HIV related Kaposi's sarcoma (KS) who had been treated with recombinant interferon (IFN) alpha-2a to determine the role of androgens on the development of KS lesions.
METHODS
32 men with HIV related KS who had been treated with IFN were
Frequent activation of the Ki-ras oncogene at codon 12 in N-methyl-N-nitrosourea-induced rat prostate adenocarcinomas and neurogenic sarcomas.
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Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such
Plasma testosterone levels in C57BL/6J male mice: effects of age and disease.
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Plasma testosterone (T) was measured by radioimmunoassay in both healthy and diseased, mature (8-11 months) and senescent (29-31 months) C57BL/6J male mice. Pathological lesions in diseased mice included reticulum cell sarcoma and enlarged mesenteric lymph nodes. In healthy mice neither plasma T nor
Free testosterone drives cancer aggressiveness: evidence from US population studies.
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Cancer incidence and mortality are higher in males than in females, suggesting that some gender-related factors are behind such a difference. To analyze this phenomenon the most recent Surveillance, Epidemiology and End Results (SEER) database served to access cancer survival data for the US
Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines.
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OBJECTIVE
Rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in childhood, rarely affects adults, preferring male. RMS expresses the receptor for androgen (AR) and responds to androgen; however, the molecular action of androgens on RMS is unknown.
METHODS
Herein, testosterone (T) effects
Osteogenic sarcoma in a patient with aplastic anemia.
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Osteogenic sarcoma developed in a 14-year-old boy 13 years after he had partially recovered from chloramphenicol-induced aplastic anemia. A possible relationship is considered between aplastic anemia, chloramphenicol, testosterone, prednisone, and osteogenic sarcoma. Leukemia has been reported
Metabolic syndrome traits in long-term survivors of pediatric sarcoma.
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OBJECTIVE
The metabolic syndrome (MS), a cluster of central obesity, dyslipidemia, hyperglycemia, and hypertension, conveys an increased risk of type 2 diabetes and cardiovascular disease. This cross-sectional study investigated the prevalence of metabolic syndrome traits (MST) in long-term
Depression of hepatic drug metabolism in endotoxin-treated and sarcoma-bearing mice.
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The effect of a single dose of bacterial endotoxin (lipopolysaccharide, LPS) was compared with that of tumor implantation in mice on the activity of several hepatic cytochrome P-450-dependent monooxygenases. These included ethoxycoumarin O-deethylase, p-nitrophenol hydroxylase, aminopyrine
Enzymatic responses of transplanted tumour cells towards estrogen, progesterone and testosterone.
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The influence of estrogen, progesterone and testosterone on the activities of alkaline and acid phosphatases, adenosine triphosphatase and succinate dehydrogenase were determined by cytochemical methods in sarcoma 180 and Ehrlich's carcinoma cells transplanted in male and female Swiss mice. The
Enzymatic responses of transplanted tumour cells towards estrogen, progesterone and testosterone.
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The influence of estrogen, progesterone and testosterone on the activities of alkaline and acid phosphatases, adenosine triphosphatase and succinate dehydrogenase were determined by cytochemical methods in sarcoma 180 and Ehrlich's carcinoma cells transplanted in male and female Swiss mice. The
[Sex and pituitary hormone secretion in adolescents with osteogenic sarcoma and retarded sexual development].
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Basal levels of secretion of total testosterone, estradiol-17 beta, their free, albumin-binding and sex steroid-binding globulin (SSBG)--binding fractions, luteinizing hormone, follicle-stimulating hormone, prolactin and somatotropic hormone were measured in blood serum in the following groups of
[Sex and pituitary hormone secretion in normal-height and tall adolescents with primary osteogenic sarcoma].
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The paper deals with a comparison of basal levels of secretion of total testosterone (T) and estradiol-17 beta (E2), their free and albumin and sex-steroid-binding globulin fractions as well as LH, FSH, prolactin and STH in blood serum of 60 normal height and 60 tall healthy adolescents and those
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