thalictrum cultratum/leukemia

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[Anti-tumor effect of hernandezine and other components extracted from Thalictrum glandulosissimum].

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The total alkaloids of T. glandulosissimum and its main component hernandezine were found to be effective for treatment of mice bearing P388 leukemia, S180 ascites and C26 colon cancer. Although hernandezine inhibited the growth of mouse L1210 cells and human oral cancer KB cells in vitro markedly,

Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of Thalictrum cultratum.

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Inspired by the intriguing structures and bioactivities of dimeric alkaloids, 11 new thalifaberine-type aporphine-benzylisoquinoline alkaloids, thalicultratines A-K, a tetrahydroprotoberberine-aporphine alkaloid, thalicultratine L, and five known ones were isolated from the roots of Thalictrum

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