thalictrum flavum/neoplasms

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Apoptosis of human highly metastatic lung cancer cell line 95-D induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium.

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The present study demonstrates for the first time that acutiaporberine, a bisalkaloid isolated from the tranditional Chinese medical herb Thalictrum acutifolium (Hand.-Mazz.) Boivin. (TAB), induces apoptosis of a cultured highly metastatic human lung cancer cell line 95-D. Immunohistochemistry assay

Apoptosis of a human non-small cell lung cancer (NSCLC) cell line, PLA-801, induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium (Hand.-Mazz.) Boivin.

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Acutiaporberine is a novel ether-linked bisalkaloid isolated from the traditional Chinese medicinal herb Thalictrum acutifolium (Hand.-Mazz.) Boivin (TAB). The present study demonstrates for the first time, by means of nuclear staining, DNA agarose gel electrophoresis, and flow cytometry, that

[Anti-tumor effect of hernandezine and other components extracted from Thalictrum glandulosissimum].

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The total alkaloids of T. glandulosissimum and its main component hernandezine were found to be effective for treatment of mice bearing P388 leukemia, S180 ascites and C26 colon cancer. Although hernandezine inhibited the growth of mouse L1210 cells and human oral cancer KB cells in vitro markedly,

Tumor inhibitors. XLII. Thalidasine, a novel bisbenzylisoquinoline alkaloid tumor inhibitor from Thalictrum dasycarpum.

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Cytotoxic isoquinoline alkaloids from the roots of Thalictrum foliolosum.

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Phytochemical investigation on the 70% EtOH extract of the roots of Thalictrum foliolosum DC. resulted in the isolation of three new isoquinoline alkaloids, 5,6,7,12-tetramethoxy-2-methyl-13-hydroxy-11-(4'-methoxycarbonylphenoxy)benzylisoquinoline (1),

Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.

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From Thalictrum faberi, thalifaberidine [1], a new aporphine-benzylisoquinoline alkaloid, together with four known alkaloids, thalifaramine [2], thalifaricine [3], thalifarazine [4], and thalifaronine [5], were isolated. Thalifaberidine [1] was identified as 6',8-desmethylthalifaberine, and its 1H-

A triterpenoid from Thalictrum fortunei induces apoptosis in BEL-7402 cells through the P53-induced apoptosis pathway.

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Thalictrum fortunei S. Moore, a perennial plant distributed in the southeastern part of China, has been used in Traditional Chinese Medicine for thousands of years for its antitumor, antibacterial and immunoregulatory effects. In order to investigate the active components and the mechanism of the

Comparison of Anticancer Activity and HPLC-DAD Determination of Selected Isoquinoline Alkaloids from Thalictrum foetidum, Berberis sp. and Chelidonium majus Extracts.

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Background: Plants are an important origin of natural substances that the raw material for various pharmaceutical and therapeutic applications due to the presence of phytochemicals, such as alkaloids. Alkaloids, which are found in different plant species, possess numerous biological

Thalictrum minus L. ameliorates particulate matter-induced acute lung injury in mice

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Ethnopharmacological relevance: Thalictrum minus L., which is widespread across Eurasia, is utilized as a folk medicine for treating dysentery, bedsore, fungal infection and lung inflammation in China, Mongolia and Iran.

Cycloartane triterpenoid saponins from the herbs of Thalictrum fortunei.

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Six new cycloartane triterpenoid saponins, thalisides A-F (1-6), along with four known ones (7-10), were isolated from Thalictrum fortunei. The new structures were elucidated by using spectroscopic data (NMR, IR, UV, and MS). Compounds 1-10 were examined for their in vitro cytotoxicity against two

Two new saponins from Thalictrum fortunei.

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Two new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae). The chemical structures of these compounds were elucidated as 3-O-β-D-glucopyranosyl (1 → 4)-β-d-fucopyranosyl-(22S,24Z)-cycloart-24-en-3β,22,26,30-tetraol 26-O-β-D-glucopyranoside and

Three new isoquinoline alkaloids from the whole plants of Thalictrum tenue with cytotoxic activities.

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Three new isoquinoline alkaloids, including two aporphines (1 and 2) and one oxoaporphine (3), were isolated from the 90% EtOH extract of the whole plants of Thalictrum tenue Franch. The structures of the isolated compounds were established based on 1D and 2D (¹H-¹H COSY, HMQC,

The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury.

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Thalictrum minus L., a Mongolian folk medicinal plant, was applied for the treatment of bacterial and fungal infection, tuberculosis and lung inflammation.The present work aims to elucidate the protective effects of Thalictrum minus L.(TML) against

Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of Thalictrum cultratum.

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Inspired by the intriguing structures and bioactivities of dimeric alkaloids, 11 new thalifaberine-type aporphine-benzylisoquinoline alkaloids, thalicultratines A-K, a tetrahydroprotoberberine-aporphine alkaloid, thalicultratine L, and five known ones were isolated from the roots of Thalictrum

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