theophylline/nausea

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Ondansetron in the treatment of intractable nausea associated with theophylline toxicity.

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OBJECTIVE To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline. METHODS A 36-year-old man who ingested 6 g of sustained-release theophylline. METHODS Ondansetron 8 mg intravenously after clinical failure of other antiemetics. RESULTS Subjective relief of

Interaction between theophylline and mexiletine.

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Drugs influencing hepatic microsomal enzyme systems, such as mexiletine, may affect the elimination pattern of theophylline. The three patients reported here had a history of asthma and premature ventricular contractions, and were receiving theophylline therapy. A few days after starting the

Simultaneous treatment with terbutaline and theophylline.

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The bronchodilating effect and side-effects of theophylline and a beta 2-adrenoceptor stimulating drug (terbutaline) alone and in combination were studied in 10 adult asthmatic patients. Initially, each individual's pharmacokinetic parameters for theophylline were determined. On 3 separate days,

Ranitidine-theophylline interaction--fact or fiction?

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We report a 63-year-old woman who developed theophylline toxicity on two separate occasions after the addition of ranitidine to her drug regimen. The first incident occurred during hospitalization, when the patient developed classical signs of theophylline toxicity (e.g., nausea, anxiousness,

Theophylline and antiparasitic drug interactions. A case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adults.

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To determine a change in theophylline pharmacokinetics during concomitant thiabendazole or mebendazole therapy, we studied six normal, healthy male volunteers. Aminophylline was administered intravenously, followed by a 30-h blood sampling period. Subjects were randomized to receive thiabendazole or

Theophylline does not increase ventilatory responses to hypercapnia or hypoxia.

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Theophylline is commonly believed to stimulate central respiratory centers. We studied the effect of oral theophylline therapy on ventilatory responses to hypercapnia and hypoxia during a double-blind placebo-controlled trial with a slow release oral theophylline preparation. We measured hypercapnic

Effect of ethanol on theophylline absorption in humans.

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This study was carried out to determine if ethanol, which enhances theophylline absorption from the rat small intestine, has a similar effect when administered orally to human subjects. Seven normal adults received 200 mg of theophylline/m-2 of body surface area, in 50 ml of either aqueous solution

Rectal administration of theophylline in aqueous solution.

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Theophylline has a narrow therapeutic index which complicates rapid effective administration. Therapeutic serum levels without toxic concentrations can usually be achieved only by a 20 min intravenous administration. In the present study 20 children were given a single dose of theophyllinne in

Evaluation of long-term oral administration of a sustained release theophylline preparation in children with chronic asthma.

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Over a one-year-period 23 children with chronic asthma were given an oral sustained-release theophylline preparation in twice-daily doses. Constant therapeutic theophylline levels were maintained in 18 children for the whole period, while in 5 subjects the values were in almost all instances below

Long-lasting protective effect of slow-release theophylline on asthma induced by ultrasonically nebulized distilled water.

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We investigated the intensity and duration of the effect of a single dose of slow-release theophylline on bronchial hyperresponsiveness to ultrasonically nebulized distilled water in asthma. In six subjects with a history of mild asthma, we measured airway responsiveness to ultrasonically nebulized

Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children.

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Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy. The theophylline was more effective and produced reduction in salbutamol usage as well as an increase in peak expiratory flow rates. Transient

A controlled comparison of slow-release theophylline, ketotifen and placebo in the prophylaxis of asthma in young children.

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A double blind crossover comparison of slow-release theophylline, ketotifen and placebo was carried out in 18 young children with perennial asthma. Theophylline significantly reduced symptoms and increased the mean peak expiratory flow rate. Transient nausea and vomiting was commoner during

Effect of fatty diet on pharmacokinetics and pharmacodynamics of a liquid theophylline preparation in volunteers.

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The effect of a standard breakfast and a fatty breakfast on the pharmacokinetics and pharmacodynamics of a theophylline liquid preparation (160 mg-single dose) was examined in 6 healthy, non-smoking male volunteers. The plasma theophylline concentrations after both standard and fatty diet were found

Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma.

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The effects of a new inhaled antimuscarinic drug, oxitropium bromide, and of a slow-release theophylline preparation upon nocturnal asthma were compared in a placebo-controlled double-blind study. Two samples were studied: 12 patients received oxitropium at 600 micrograms (6 subjects) or at 400

[Inhibition of uterine contraction using theophylline--experimental and clinical studies].

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The tocolytic efficiency of theophylline was investigated in 24 uterine strips and in 31 patients with premature contractions. Frequency, duration, amplitude, area and activity of the strips spontaneous contractions were decreased highly significantly (p less than 0.01) after administration of

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