theophylline/potato

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Robustness of Controlled Release Tablets Based on a Cross-linked Pregelatinized Potato Starch Matrix

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The aim of this study was to evaluate the potential of a cross-linked pregelatinized potato starch (PREGEFLO® PI10) as matrix former for controlled release tablets. Different types of tablets loaded with diprophylline, diltiazem HCl or theophylline were prepared by direct compression of binary

Higher-plant cyclic nucleotide phosphodiesterases. Resolution, partial purification and properties of three phosphodiesterases from potato tuber.

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1. Three phosphodiesterases that are capable of hydrolysing 3':5'-cyclic nucleotides were purified from potato tubers. 2. The phosphodiesterases were fractionated by (NH4)2SO4 precipitation and CM-cellulose chromatography. The phosphodiesterases were resolved from each other and further purified by

Invivo absorption behaviour of theophylline from starch-methyl methacrylate matrix tablets in beagle dogs.

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This study evaluates in vivo the drug absorption profiles from potato starch-methyl methacrylate matrices(*) using theophylline as a model drug. Healthy beagle dogs under fasting conditions were used for in vivo studies and plasma samples were analyzed by a fluorescence polarization immunoassay

Bioadhesive grafted starch copolymers as platforms for peroral drug delivery: a study of theophylline release.

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Nonirritant bioadhesive drug release systems based on starch-acrylic acid graft copolymers prepared by radiation of starch and acrylic acid mixtures with (60)Co were developed for buccal application. The release rate of theophylline (TPL), used as a model drug, depended on the ratio of starch to

A new generation starch product as excipient in pharmaceutical tablets. III. Parameters affecting controlled drug release from tablets based on high surface area retrograded pregelatinized potato starch.

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This paper describes the general applicability of a new pregelatinized starch product in directly compressible controlled-release matrix systems. It was prepared by enzymatic degradation of potato starch followed by precipitation (retrogradation), filtration and washing with ethanol. The advantages

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets.

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The relationship between lubricant-mixing time and dissolution time was investigated, and we established a calibration model to predict dissolution time by near infrared (NIR) spectroscopy and the rationale of the prediction. The bulk powder consisted of theophylline, lactose, and potato starch were

Real-time-monitoring of pharmaceutical properties of medical tablets during direct tableting process by hybrid-tableting-process parameter-time profiles.

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Real-time monitoring is required for the pharmaceutical manufacturing process to produce high-quality pharmaceutical products.Changes in the critical tableting process parameters of single-punch tableting machine due to variability in the moisture content

Preparation of drug-diluent hybrid powders by dry processing.

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New hybrid powders have been produced by the dry processing of six drugs (oxyphenbutazone, prednisolone, theophylline, indomethacin, phenacetin and aspirin), with potato starch used as a core material, by means of an electric mortar and a powder surface reforming system designed to produce hybrid

In vitro release testing of matrices based on starch-methyl methacrylate copolymers: effect of tablet crushing force, dissolution medium pH and stirring rate.

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Direct-compressed matrix tablets were obtained from a variety of potato starch-methyl methacrylate copolymers(1) as sustained-release agents, using anhydrous theophylline as a model drug. The aim of this work was to investigate the influence of the copolymer type, the tablet crushing force and

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