thymoma/seizures

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Paraneoplastic extra limbic encephalitis associated with thymoma.

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We report the case of a 55-year-old woman with thymoma diagnosed after finding of extra limbic encephalitis. She presented neurologic symptoms as seizure and aphasia; magnetic resonance imaging (MRI) of the brain showed multiple lesions located in insular, parietal and temporal lobes (in cortical

Recurrent limbic and extralimbic encephalitis associated with thymoma.

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A 33-year-old woman, with a 7-year clinical history of invasive thymoma treated at ages 26 and 30 years by thymectomy and radiation, presented with a generalized convulsion and loss of consciousness. Following the seizure there was no neurological deficit and normal tendon reflexes. Magnetic

Multifocal paraneoplastic cortical encephalitis associated with myasthenia gravis and thymoma.

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OBJECTIVE To report a case of multifocal cortical encephalitis associated with thymoma and to establish an association of this thymoma-related paraneoplastic syndrome with voltage-gated potassium channel antibodies. METHODS Case report. METHODS University hospital. METHODS A 43-year-old woman with a

Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma.

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Recently, limbic encephalitis (LE) associated with Voltage-gated potassium channel antibody (VGKC-Ab) has been postulated as a new autoimmune disorder. Most previously reported cases of VGKC-Ab-associated LE were non-paraneoplastic, and reports of a paraneoplastic type are rare. Here we describe a

V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.

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Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Here, we have performed a prospective nationwide genetic association study using the Human Exome BeadChip and identified gene

Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis.

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A 59-year-old man presents with expressive aphasia and short term memory deficits. Shortly thereafter, he started developing staring spells and intermittent right hand spasms, preliminarily thought to be simple partial seizures. Subsequent MRI brain imaging was highly suggestive of herpes simplex

Fulminant autoimmune cortical encephalitis associated with thymoma treated with plasma exchange.

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A 55-year-old man presented with fever, malaise, dysarthria, and intermittent twitching of his right hand. He progressed rapidly to aphasia, intractable myoclonic seizures, and unresponsiveness. Magnetic resonance imaging (MRI) of the head demonstrated multiple nonenhancing areas of signal

Isolated seizures are a common early feature of paraneoplastic anti-GABAB receptor encephalitis.

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OBJECTIVE To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABAB receptor antibodies (GABABR-Abs). METHODS Retrospective clinical study of CSF-confirmed cases of GABABR-Abs encephalitis. RESULTS We identified 22 patients (4 female) with

Amygdaloid kindled seizures can induce functional and pathological changes in thymus of rat: role of the sympathetic nervous system.

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The present study sought to determine the effects of long-term kindled seizures of the basal amygdala upon immune function in rat, utilizing the thymus, as a principal target for study. Histopathology from kindled Sprague-Dawley rats revealed the presence of epithelial cell thymoma in 70% of these

Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.

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Autoantibodies against contactin-associated protein-like 2 (CASPR2) are observed in several neurological syndromes, including neuromyotonia (NMT), Morvan syndrome (MoS), and limbic encephalitis. To characterize the clinical and biological presentations of patients with anti-CASPR2 antibodies in the

Clinical spectrum of voltage-gated potassium channel autoimmunity.

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OBJECTIVE To document neurologic, oncologic, and serologic associations of patients in whom voltage-gated potassium channel (VGKC) autoantibodies were detected in the course of serologic evaluation for neuronal, glial, and muscle autoantibodies. METHODS Indirect immunofluorescence screening of sera

Morvan Syndrome (Morvan Fibrillary Chorea, MFC)

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Morvan syndrome or Morvan’s fibrillary chorea (MFC) is a rare constellation of neurological symptoms, consisting of peripheral nerve hyperexcitability, autonomic instability, and encephalopathy often associated with autoantibodies to voltage-gated potassium channel complexes (VGKCs). On 12

Thymic Lymphoid Hyperplasia With Graves' Disease in a 28-year-old Female: A Case Report

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Thymic lymphoid hyperplasia with Graves' disease (GD) is not uncommon in adults. Generally, cases are newly diagnosed with GD when they refer to the department of endocrinology in hospital, and an anterior mediastinal mass is found on a computed tomography scan by accident. Almost half of them

[Limbic encephalitis with antibodies against intracellular antigens].

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Limbic encephalitis is a paraneoplastic syndrome that is often associated with small cell lung cancer (SCLC), breast cancer, testicular tumors, teratoma, Hodgkin's lymphoma and thymoma. The common clinical manifestations of limbic encephalitis are subacute onset, cognitive dysfunction, seizures and

[Limbic encephalitis and variants related to neuronal cell membrane autoantigens].

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Limbic encephalitis refers to an inflammatory process involving the hippocampi. amygdala and less frequently frontobasal and insular regions. This disorder used to be considered extremely rare, invariably associated with cancer, and unresponsive to treatment. However, recent studies suggest that

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