BACKGROUND
Allergen extracts can degrade when exposed to temperatures significantly beyond the optimum storage recommendation of 4 degrees C. Many allergen extracts are mailed to their final destinations throughout the year with exposure to varied environmental conditions.
OBJECTIVE
To evaluate the
BACKGROUND
Due to the interest in azelastine's diverse modes of action, this study investigated its effects on immediate and late-phase cutaneous allergic reactions using visual methods and telethermography.
OBJECTIVE
The aim of the study was to investigate the effect of azelastine on the immediate
Twelve patients with seasonal allergic conjunctivitis caused by either birch or timothy grass pollen were challenged out of season in both eyes, with the relevant allergen. Itching, redness, swelling, and tearing were assessed on a 0-3 scale. When a positive reaction, i.e., at least 4 points, had
The Food and Drug Administration, Center for Biologics Evaluation and Research (CBER) has developed methodology to standardize both aqueous and freeze-dried (lyophilized) extracts. Thus far, it has not been determined whether or not this methodology can be used to standardize alum-adsorbed extracts.
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