tooth mobility/protease

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Clinical, genetic, and biochemical findings in two siblings with Papillon-Lefèvre Syndrome.

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BACKGROUND Papillon-Lefèvre Syndrome (PLS) is an autosomal recessive disease characterized by palmoplantar hyperkeratosis and severe periodontitis affecting both primary and secondary dentitions. Cathepsin C (CTSC) gene mutations are etiologic for PLS. The resultant loss of CTSC function is

Phenotypic overlap of Ehlers-Danlos syndrome types IV and VIII.

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An 18-year-old Caucasian woman has been followed since age 12 years for Ehlers-Danlos syndrome (EDS) with easy bruisability and "cigarette paper scars." Her chief complaint at age 17 years was tooth mobility, especially in the anterior mandible, necessitating the removal of the four incisors.

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