topotecan/infarction

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Topotecan in chronic lymphocytic leukemia.

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BACKGROUND Topotecan is one of a new class of agents that targets topoisomerase I (Topo I) and stabilizes the DNA-topo1 complex, ultimately resulting in cell death. The rationale for the use of topotecan in chronic lymphocytic leukemia (CLL) is based on the finding that levels of Topo I are elevated

Cranial metastatic alveolar rhabdomyosarcoma mimicking hematological malignancy in an adolescent boy.

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BACKGROUND Widespread alveolar rhabdomyosarcoma (ARMS) with bone marrow involvement and with an unknown primary tumor, especially presenting with acute tumor lysis syndrome can be easily misdiagnosed as a hematological malignancy. Furthermore, brain metastasis of ARMS is rare seen in

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