trans communic acid/cupressus

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Osteogenic activity of natural diterpenoids isolated from Cupressus sempervirens fruits in calvarial derived osteoblast cells via differentiation and mineralization.

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The aim of the present study was to investigate the antiosteoporotic activity of four structurally related diterpenoids: sugiol (1), trans-communic acid (2), 15-acetoxy imbricatolic acid (3) and imbricatolic acid (4). Their osteogenic effect was evaluated by using validated models including alkaline

Antitumour lignans and cytotoxic resin acids from a New Zealand gymnosperm, Libocedrus plumosa.

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The antitumour activity of a foliage extract of a New Zealand gymnosperm, Libocedrus plumosa, against P388 leukaemia cells was due to β-peltatin 3. Deoxypodophyllotoxin 1 and β-peltatin A-methyl ether 2, P388-active lignans previously reported in L. bidwillii, were found at lower levels. High levels

Novel merosesquiterpene exerts a potent antitumor activity against breast cancer cells in vitro and in vivo.

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This article describes the antitumor properties of a new family of merosesquiterpenes, which were synthesized by Diels-Alder cycloaddition of the labdane diene trans-communic acid, highly abundant in Cupressus sempervirens, or its methyl ester, with the appropriate dienophile. These compounds

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