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Ivermectin and Nitazoxanide Combination Therapy for COVID-19

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Selected Drugs Ivermectin has anti-parasitic effect along with anti-viral activity against a broad range of viruses in vitro. Ivermectin was identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer

Robotic vs. TaTME Rectal Surgery (ROTA STUDY)

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Introduction Colorectal cancer (CRC) is the fourth most common malignant disease with over 1 million new cases each year worldwide (1) The outcome of surgery for rectal cancer has improved substantially during the past two decades due to TME, which involves complete removal of the mesorectum with

The Swedish Essential Tremor (SWEET) Trial

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PURPOSE AND AIMS - Aim 1 - To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial. - Aim 2 - To compare the effect of DBS in the established target in the ventrolateral (VL)-thalamus/ nucleus

Optic Nerve Sheath Diameter As A Predictor Of Early Tacrolimus Neurotoxicity In Living Donor Liver Transplantation

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Neurotoxicity is mainly associated with tacrolimus and cyclosporin, amounting to 10 - 30% for CS and up to 32% for tacrolimus.(2) . Sirolimus, everolimus, and mycophenolate mofetil lack the neurotoxicity of calcineurin inhibitors (3-4). Neurotoxicity mostly occurs in the early postoperative period

Optimization of VIM Targeting in Essential Tremor Surgery

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The intermedius ventralis nucleus of the thalamus (VIM), which represents the target for deep brain stimulation (DBS) in essential tremor, still remains invisible on 1,5 tesla MRI (the only magnetic field available for stereotactic surgery). The target coordinates currently used are based on

Probabilistic Targeting of the VIM

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The intermedius ventralis nucleus of the thalamus (VIM), which represents the target for deep brain stimulation (DBS) in essential tremor, still remains invisible to imaging in spite of the development of new MR sequences. The coordinates currently used in the classical (ACPC) system are so

The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.

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Stroke or unsufficient cerebral circulation is a non-traumatic disease due to occlusion or rupture of brain blood circulation characterized by neurological deficits such as loss of motor control, cognitive impairment, oral disorder or sensory changes in one half of the body resulting from changes.

To Evaluate the Robotic Surgery in a Dedicated Multidisciplinary Pediatric Program and the Relative Cost of Robotic Surgery

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Laparoscopy has been adopted for advantages that include decreased adhesion formation, improved cosmesis, decreased post-operative pain, and shorter recovery times. The patient benefits of robotic surgery are thought to be essentially the same as conventional laparoscopy: decreased length of stay,

Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.

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Specific aims: -Determine if infiltrating the cervical stroma with local anesthetic prior to performing a hysterectomy will reduce postoperative pain scores, and hence increase patient satisfaction. Secondary aims: - Determine if there is a difference in baseline pain depending on additional

Subthalamotomy by ExAblate Transcranial System to Treat Motor Features of Parkinson's Disease

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This ExAblate Transcranial system was built atop the ExAblate Body system technology, which has received EMA and CE approvals for the treatment of uterine fibroids and bone metastasis palliation, and is currently being evaluated under various EMA Investigational Device Exemptions "IDE". It should be

Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders

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BACKGROUND Obsessive‐Compulsive Disorder [OCD] is a psychiatric disorder with a lifetime prevalence of 2% which is mainly characterized by obsessional ideas and compulsive behaviours and rituals. Many patients show improvement under cognitive behavioural and/or pharmacological treatment. A minority

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

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1.0 Background While atrial fibrillation (AF) is the most common sustained cardiac arrhythmia requiring therapy, it is also associated with increased risk of stroke, heart failure, myocardial infarction, dementia, and death. The number of Americans affected with AF is expected to surge to nearly 16

High and Low Dose Carbidopa Treatment of Parkinson's Disease

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A. Specific Aims: Parkinson's disease is a common neurodegenerative disorder characterized by the progressive motor symptoms of tremor, rigidity, and bradykinesia. The prevalence is estimated at 102-109/100,000 and increases with age. It is the second most common neurodegenerative disorder after

Glutathione (GSH) In The Treatment of Parkinson's Disease

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Inclusion Criteria Idiopathic Parkinson's disease (2 of 3 of the cardinal symptoms, tremor, bradykinesia, rigidity) Mini Mental State Examination > 24 Anti-parkinsonian medications stable for one month Hoehn and Yahr II-IV Exclusion Criteria Atypical parkinsonism History of seizure, drug addiction

Postoperative Distress and Cosmetic Outcomes After Open Versus Robotic Thyroidectomy

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Patient assessment A prospective study addressing perioperative outcomes and postoperative patient discomfort after thyroidectomy was commenced in April 2009 and is currently continuing. All patients were told about the operative techniques involved in conventional open and robotic thyroidectomy,

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