The ursane triterpenoid alpha-amyrin and the lupane triterpenoid lupeol are potent inhibitors of the catalytic subunit (cAK) of rat liver cyclic AMP-dependent protein kinase (PKA) with IC50 values of 8 and 5 microM, respectively. The palmitate and linoleate esters of alpha-amyrin and lupeol are also
OBJECTIVE
To study the biotransformation of cycloartan-24-ene-1alpha,2alpha, 3beta-triol isolated from myrrh and find new antitumor bioactive cycloartane-type derivatives.
METHODS
Fourteen microbial strains were cultured in potato medium at 27.8 degrees C for 7 days. The strain of Penicillium
The scale insect pathogens Hypocrella s. lat. and their Aschersonia anamorphs, collected at various locations in Thailand, were surveyed for their productivity of three hopane triterpenes, zeorin (6alpha,22-dihydroxyhopane), dustanin (15alpha,22-dihydroxyhopane), and
Submerged cultures of Ganoderma lucidum are used to produce fungal mycelium, which is used as a functional food and in the production of various triterpenoids, including ganoderic acids (GAs). Specific culture approaches that produce fungal mycelium with high levels of GAs and good biological
BACKGROUND
Malaria is one of the most common and serious protozoan tropical diseases. Multi-drug resistance remains pervasive, necessitating the continuous development of new antimalarial agents.
OBJECTIVE
Many glycosides, such as triterpenoid saponins, were shown to have antimalarial activity
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