BACKGROUND OF THE INVENTION
Trypanosomiasis, malaria, and leishmaniasis are major parasitic diseases in developing countries (McKerrow, J. H. et al., Annu. Rev. Microbiol. 47:821-853 (1993)). American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in Latin America (Libow,
BACKGROUND OF THE INVENTION
Trypanosomiasis, malaria, and leishmaniasis are major parasitic diseases in developing countries (McKerrow, J. H. et al., Annu. Rev. Microbiol. 47:821-853 (1993)). American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in Latin America (Libow,
BACKGROUND OF THE INVENTION
A major class of proteases involved in the etiology of disease are the cysteine proteases. Cysteine proteases share a common proteolytic mechanism that requires a nucleophilic cysteine thiol in the active site of the protease. Examples of cysteine proteases include
BACKGROUND OF THE INVENTION
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions Inhibition of these proteases can be useful in the treatment and/or prevention of these parasitic diseases, see Lecaille, F., et al, Chem. Rev., 102,
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