ulcer/scopolamine

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Effects of transdermal scopolamine, alone or in combination with cimetidine, on total 24 hour gastric acid secretion in patients with duodenal ulcer.

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Transdermal scopolamine is an antimuscarinic preparation approved for use in the United States for prevention of motion sickness. A recent study using this drug (0.5 mg/patch) suggested that enough scopolamine was absorbed through the skin to reduce basal gastric acid secretion in patients with

[Effects of an anticholinergic, scopolamine N-butylbromide on painful evolutive spasms of gastroduodenal ulcer].

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The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang.

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The influence of synthetic drugs prescribed for peptic ulcer on the pharmacokinetic fate of glycyrrhizin (GL) from Shaoyao-Gancao-tang (SGT, a traditional Chinese formulation, Shakuyaku-Kanzo-to in Japanese) was investigated in rats. Co-administration of histamine H2-receptor antagonist (cimetidine)

Effects of manipulating cholinergic tone upon the activity-stress ulcer.

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Eighty rats were housed in standard activity wheel cages and fed for only 1 hr per day. The animals were divided into 10-animal drug groups that received either 0.25, 050, 1.0 mg/kg of scopolamine methylbromide, or 0.06, 0.125, 0.250 mg/kg of carbachol, 3 times a day. Two separate 10-animal saline

Controlled retrospective study of the effects of eyedrops containing phenylephrine hydrochloride and scopolamine hydrobromide on mean arterial blood pressure in anesthetized dogs.

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OBJECTIVE To determine whether dogs that received eyedrops containing phenylephrine and scopolamine would have a higher mean arterial blood pressure (MAP) when anesthetized than would dogs that did not receive the eyedrops. METHODS 37 nondiabetic and 29 diabetic dogs anesthetized for

Restraint ulcer: history, current research and future implications.

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A relatively new ulcerogenic procedure, supine restraint-cold, is described. This procedure is simple, effective andproduced a reliably high incidence of gastric glandular lesions in a variety of animal species. In some cases, these lesions penetrate the muscularis mucosa and as such may be called

Antiamnesic and Antioxidants Effects of Ferulago angulata Essential Oil Against Scopolamine-Induced Memory Impairment in Laboratory Rats.

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Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%,

Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice.

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BACKGROUND Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of T. chebula has not yet been investigated. The present study was designed to

Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models.

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In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The present study was undertaken to investigate the effects of G. glabra,

Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade.

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Experimental and clinical evidence documents the beneficial effects of blocking sympathetic activity and modulating heart rate to reduce risk for lethal events in ischemic heart disease. Beside beta-adrenergic receptor blockade, vagal activation is a meaningful approach but not yet easily

[Effect of scopolia drugs on the gastric mucosal lesion in rats].

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In the present paper, effects of scopolia drugs (scopolamine, anisodine, anisodamine) on experimental gastric mucosal lesion models in rats were investigated. Scopolia drugs were found to be effective anti-ulcer agents in three experimental gastric ulcer models (i.e. cold-restraint stress induced

Cardiopulmonary complications during gastroscopy in patients with chronic respiratory failure undergoing long-term home oxygen therapy.

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OBJECTIVE Gastric ulcer and hemorrhage are major complications in patients with chronic respiratory failure, but upper GI endoscopy tends to be avoided because of possible cardiopulmonary events. This study was designed to evaluate hypoxemia and subsequent cardiac complications during gastroscopic

Pirenzepine, telenzepine, atropine and metacine as agonists for the muscarinic cholinoreceptors in the denervated human parotid gland.

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New anti-ulcer preparations, pirenzepine and telenzepine, are structurally dissimilar to the classical cholinomimetics, atropine and hyoscine (scopolamine). However, they are all capable of provoking paradoxical salivation from the chronically parasympathetically denervated human parotid gland. The

Antihyperglycemic, antistress and nootropic activity of roots of Rubia cordifolia Linn.

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Effect of alcoholic extract of roots of Rubia cordifolia was studied on elevated blood glucose level in alloxan treated animals. The extract reduced the blood sugar level raised by alloxan. Effect of alcoholic extract was also investigated on cold restraint induced stress and on scopolamine-induced

Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice.

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BACKGROUND Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with

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