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vasoactive intestinal peptide/neoplasms
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9 results
Vasoactive intestinal peptide analogs
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FIELD OF THE INVENTION
The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing .alpha.,
Vasoactive intestinal peptide analogs
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FIELD OF THE INVENTION
The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing
Use of protein biomolecular targets in the treatment and visualization of brain tumors
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FIELD OF USE
The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of
Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
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FIELD OF THE INVENTION
The present invention encompasses radiolabeled peptide analogs of vasoactive intestinal peptide (VIP) labeled with a radionuclide useful for imaging target sites within mammalian living systems. The invention particularly provides radiolabeled VIP derivatives that bind
Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy
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FIELD OF THE INVENTION
This invention relates generally to the field of nuclear medicine and, more particularly to, radiolabeled agents for imaging tumors, methods of use of said agents, and kits for preparing imaging agents.
BACKGROUND OF THE INVENTION
Cancer remains a major health problem among
Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy
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FIELD OF THE INVENTION
This invention relates generally to the field of nuclear medicine and, more particularly to, radiolabeled agents for imaging tumors, methods of use of said agents, and kits for preparing imaging agents.
BACKGROUND OF THE INVENTION
Cancer remains a major health problem among
Methods of managing graft versus host disease
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BACKGROUND
Certain stem cells and T cells originate in bone marrow and circulated in the blood. One option for treating cancers of the blood and bone marrow is to kill existing cells, e.g., through radiation or chemotherapy, and transplant similar cells from a healthy donor, referred to as an
Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to one-vial methods and kits for radiolabeling peptides with a radiometal ion of a radionuclide that binds tightly to sulfhydryl groups, wherein the peptide is derivatized with a tertiary thiol-containing chelating agent. A
Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use
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FIELD OF THE INVENTION
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC.sub.1, VPAC.sub.1 and VPAC.sub.2 receptors. These PACAP analogs can be used as
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