vulvar neoplasms/vinca

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Preclinical antitumor activity of a new Vinca alkaloid derivative, S 12363.

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S 12363 is a new Vinca alkaloid derivative obtained by appending an optically active alpha-aminophosphonate at the C23 position of O4-deacetyl vinblastine. S 12363 was evaluated for cytotoxic and antitumor activity against a spectrum of murine and human tumors. This compound was, respectively, on

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