The ethanol extract of Wikstroemia indica was fractionated with organic solvents of different polarities, and various fractions were screened for their antiviral activity against respiratory syncytial virus (RSV) using a cytopathic effect (CPE) reduction assay. The ethyl acetate fraction was most
A new biflavonoid, 4'-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of extensive spectroscopic data including HR-ESI-MS and 2D NMR. The biflavonoid was tested for its in vitro
Phytochemical investigation of the roots of Wikstroemia indica led to the isolation of four new dilignans (1-4). Their structures were established on the basis of the spectroscopic data including UV, IR, high resolution-electron ionization-mass spectrometry (HR-ESI-MS), 1D- and 2D-NMR (1H-1H
We examined the antiviral activity of a crude extract prepared from a Chinese medicinal herb Wikstroemia indica C.A. Mey. One active component, daphnoretin (7-hydroxyl-6-methoxy-3,7'-dicoumarylether), was identified, which showed strong suppressive effects on the expression of the hepatitis B
Daphnoretin is a bicoumarin compound isolated from a natural product, Wikstroemia indica, which has been used to treat many diseases. It has strong antiviral and anti-tumor activities. Taking the anti-tumor activity of daphnoretin as a starting point, the present study aimed to test the
Wikstroemia indica (L.) C. A. Mey. is a member of family Thymelaeaceae and mainly distributes in middle and southeast part of China. As a traditional Chinese herb, this plant has long been employed as antipyretics, detoxicants, expectorants, vermifuges as well as aborticides in clinic practice.
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