Changes in the glycosaminoglycans, glycoproteins and lipid components of erythrocyte membrane in neuroacanthocytosis.

Changes in the glycosaminoglycans (GAG), glycoproteins (GP) and lipid components of erythrocyte membrane were studied in two patients of neuroacanthocytosis, as compared to normal, control subjects. Concentration of GAG, decreased in the erythrocytemembrane in patients of neuroacanthocytosis while the carbohydrate components of the glycoproteins showed alterations both quantitatively and qualitatively. The ratio of W6 to W3 fatty acids showed increase in the erythrocyte membrane in neuroacanthocytosis patients while the ratio of cholesterol to phospholipids was decreased.