Zeitschrift fur Rheumatologie 2012-Jan
[Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases].
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Abstracto
Chronic inflammatory diseases are characterized by hypoxia and subsequent cellular adaptation via hypoxia-inducible factor (HIF). Modulation of these adaptation mechanisms provides the basis for ideas on how to improve the effects of known drugs and for the development of novel therapeutic approaches.