[Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection (observation of 60 cases)].
Palabras clave
Abstracto
OBJECTIVE
To evaluate the efficacy of treating malignant pleural effusion with cisplatine and vindesine by injection through thoracic tube intubation.
METHODS
60 cases with malignant pleural effusion, after drainage, vindesine 4 mg, cisplatine 40 mg/m(2) were injectred into pleural cavity in therapy group (T), and only cisplatine 40 mg/m(2) in control group (C). the tretment was repeated after a week, then evaluate the efficacy, survival rate, toxicities and quality of life.
RESULTS
The response rate was 81% in T group and 50% in C group. There was statistical difference in two groups (P < 0.05). The Karnofsky score is higher in T group than in C group. The half-year, one-year, one and half-year, two-year survival rates were 97%, 59%, 44%, 6% in T group and 71%, 50%, 14%, 4% in C group. Grade I leukopenia is higher in T group than in C group.
CONCLUSIONS
The treatment to use Vindesine and cisplatine through thoracic tube is regarded as effective, slight side-effect and well tolerated method for malignant pleural effusion.
