[Trichosporon antibodies (corrected of antigen) and HLA-antigen in summer-type hypersensitivity pneumonitis in a family].

We encountered a family in which all of the three members (the parents, a 45-year-old woman and 51-year-old man, and their 15-year-old daughter) had Trichosporon cutaneum antibodies (corrected of antigen), and two (the parents) suffered from summer-type hypersensitivity pneumonitis in the late summer. The husband complained of dry cough, fever and dyspnea on exertion from July after severe interstitial pneumonitis and was treated with steroid pulse in September 2004. His wife visited our hospital and complained of a common cold-like symptom which progressed in August 2005. The couple were given diagnoses of summer-type hypersensitivity pneumonitis because they were positive for serum anti-Trichosporon mucoides antigen and asahii antigen. Their asymptomatic daughter was positive for these antigens. Both wife and daughter had HLA-DQ 8 (3) and 9 (3) that are suggested to be important HLA antigens related to the occurrence of summer-type hypersensitivity pneumonitis.