Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
Palabras clave
Abstracto
OBJECTIVE
We investigated whether tryptophan hydroxylase 2 (TPH2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication.
METHODS
Forty-seven migraine patients (6 males and 41 females; 36.4 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 9.9 years) who had migraines participated in this study. The genotypes for the TPH2 gene polymorphisms (rs4565946, rs4570625, and rs4341581) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.
RESULTS
The rs4565946, rs4570625, and rs4341581 genotypes were similarly distributed between migraine patients and MOH patients.
CONCLUSIONS
The results of this study showed no association between tryptophan TPH2 gene polymorphisms and the complication of MOH in patients with migraines.
