[ ¹⁸ F]-FDG-PET/CT and [ ¹⁸ F]-FAZA-PET/CT Hypoxia Imaging of Metastatic Thyroid Cancer: Association with Short-Term Progression After Radioiodine Therapy

Purpose: To examine the relationships between 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]-FDG) and hypoxia tracer [¹⁸F]fluoro-azomycinarabinofuranoside ([¹⁸F]-FAZA) and between ¹³¹I and [¹⁸F]-FAZA uptake in patients with metastatic thyroid cancer and to evaluate imaging features associated with short-term progression after ¹³¹I therapy.

Procedures: The study population was 20 patients (17 women and 3 men; mean age, 67 years) with metastatic thyroid cancer who underwent both [¹⁸F]-FDG- and [¹⁸F]-FAZA-positron emission tomography (PET)/X-ray computed tomography (CT) examinations before ¹³¹I therapy. Short-term response to radioiodine was assessed (mean follow-up, 19 months ± 9). PET parameters including [¹⁸F]-FDG-SUVmax, [¹⁸F]-FAZA-SUVmax, and [¹⁸F]-FAZA-tumor-to-muscle [T/M] were obtained. Mann-Whitney U, Wilcoxon signed-rank, or χ² tests were used to assess differences between two quantitative variables or compare categorical data. Predictive factors for short-term progression were investigated with logistic regression analysis.

Results: Eleven lymph node metastatic lesions were identified in 9 patients and 46 distant metastatic lesions (lung, 19; bone, 17; and liver, 10) in 14 patients. A total of 24 ¹³¹I-positive and 33 ¹³¹I-negative lesions were detected. SUVmax was significantly lower with [¹⁸F]-FAZA-PET/CT (1.3 ± 0.6) than with [¹⁸F]-FDG-PET/CT (6.4 ± 5.9, p < 0.001). No significant correlation was observed between [¹⁸F]-FAZA-PET/CT and ¹³¹I imaging concerning visibility (p = 0.36). After ¹³¹I therapy, 31 of 57 metastatic lesions displayed short-term progression. Multivariate logistic regression revealed that [¹⁸F]-FDG-SUVmax (p = 0.022) and [¹⁸F]-FAZA-T/M (p = 0.002) showed significant associations with short-term progression.

Conclusions: Although [¹⁸F]-FAZA uptake was low in metastatic thyroid cancers, not only glucose metabolism but also hypoxic conditions may be associated with progression after ¹³¹I therapy in patients with metastatic thyroid cancer.

Keywords: 131I; PET/CT; Thyroid cancer; [18F]-FAZA; [18F]-FDG.