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antidiabetic/inflamación
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Structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties
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This invention relates to novel structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties. These compounds are found to exhibit potent hypoglycemic, 5-lipoxygenase inhibitory and antitumor activities.
TECHNICAL FIELD
Diabetes is perceived as a disorder of metabolism,
Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions
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BACKGROUND OF THE INVENTION
There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2##
Among the known compounds are 1-[p-(2-aminoethyl)phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and
Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions
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The present invention is directed to processes of isolating purified compositions with or without chromium containing compounds, from a variety of natural sources including, but not limited to, a yeast strain S. carlsbergensis, or S. cerevisiae, or any commercial source of yeast extract; or from the
Pharmaceutically active extracts of vitex leucoxylon, a process of extracting the same and a method of treating diabetes and inflammatory diseases therewith
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TECHNICAL FIELD OF THE INVENTION
The present invention provides a new, non-toxic Vitex leucoxylon extract for inhibiting increase of blood sugar level or lowering blood glucose levels and a process for extracting the same from the plant material. Isolated corosolic acid from the extract is also
Use of hepoxilins or hepoxilin analogs as antidiabetics, antiinflammatory agents
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FIELD OF THE INVENTION
The present invention relates to therapeutic methods and pharmaceutical compositions employing native hepoxilins and hepoxilin analogs.
BACKGROUND OF THE INVENTION
Hepoxilins are biologically active hydroxy epoxide derivatives of arachidonic acid formed through the
Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions
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The present invention is directed to processes of isolating purified compositions with or without chromium containing compounds, from a variety of natural sources including, but not limited to, a yeast strain S. carlsbergensis, or S. cerevisiae, or any commercial source of yeast extract; or from the
Salts and polymorphs of a potent antidiabetic compound
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2. FIELD OF THE INVENTION
The present invention relates to salt forms of a potent modulator of the peroxisome proliferator-activated receptor .gamma. ("PPAR .gamma.") receptor and polymorphic forms thereof, compositions comprising the salt forms or polymorphic forms, methods of making the salt forms
Salts and polymorphs of a potent antidiabetic compound
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2. FIELD OF THE INVENTION
The present invention relates to salt forms of a potent modulator of the peroxisome proliferator-activated receptor .gamma.("PPAR.gamma.") receptor and polymorphic forms thereof, compositions comprising the salt forms or polymorphic forms, methods of making the salt forms
Method useful in the treatment of sugar cataracts using 4-substituted-2-iminoimidazolidine compounds
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BACKGROUND OF THE INVENTION
There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2##
Among the known compounds are 1-[p-(2-aminoethyl)-phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and
Pharmaceutical compositions useful in the treatment of cardiovascular hypertension and containing 4-substituted-2-iminoimadazolidine compounds
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BACKGROUND OF THE INVENTION
There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2##
Among the known compounds are 1-[p-(2-aminoethyl)phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and
Methods useful in the treatment of cardiac arrhythmia using 4-substituted-2-iminoimidazolidine compounds
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BACKGROUND OF THE INVENTION
There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2##
Among the known compounds are 1-[p-(2-aminoethyl)-phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and
4-Substituted 2-iminoimidazolidine compounds
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BACKGROUND OF THE INVENTION
There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2##
Among the known compounds are 1-[p-(2-aminoethyl)phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
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