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antimalarial/ataque epiléptico
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[A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment].
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We report a case of 40-year-old with chloroquine- and mefloquine-resistant Plasmodium falciparum. He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine. He had a long history
Antimalarial myopathy in a systemic lupus erythematosus patient with quadriparesis and seizures: a case-based review.
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Weakness, seizures, and encephalopathy have a broad differential diagnosis in patients with systemic lupus erythematosus (SLE). We present a case of a 26-year-old female with a recent diagnosis of SLE who experienced a clinical deterioration with quadriparesis, seizures, and encephalopathy. Her
[Convulsions and shock during antimalarial chemoprophylaxis with mefloquine].
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Seizures after antimalarial medication in previously healthy persons.
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Convulsions associated with prophylactic antimalarial drugs: implications for people with epilepsy.
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Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso.
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In rural, malaria-endemic Burkina Faso, we evaluated the impact of the use of pre-packaged antimalarial drugs (PPAM), by mothers in the home, on the progression of disease in children from uncomplicated fever to severe malaria. In each village of one province, a core group of opinion leaders (mainly
Benzothiophene carboxamide derivatives as novel antimalarials.
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Bromo-benzothiophene carboxamide derivatives have been shown in the preceding article to inhibit Plasmodium falciparum Enoyl-ACP reductase. Here, we report bromo-benzothiophene carboxamide derivatives as potent inhibitors of Plasmodium asexual blood-stages in vitro as well as in vivo in the mouse
Prescription pattern of antimalarial drugs in children below 5 years in a tertiary health institution in Nigeria.
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BACKGROUND
This study examines the diagnosis of malaria and pattern of prescription of antimalarial drugs in the most vulnerable age group (the under 5 children) in the study environment in order to identify the possible shortcomings and suggest solutions so as to improve the treatment outcome in
[Ophthalmological monitoring protocol for patients treated with long-term antimalarials or vigabatrin].
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Treatment with the antimalarials chloroquine or hydroxychloroquine rarely causes retinopathy. Chloroquine and hydroxychloroquine toxicity are untreatable and can progress to legal blindness. Since 1957, there has been a consensus on the need to monitor patients on long-term chloroquine or
Epileptogenic potential of antimalarial drugs.
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Available clinical reports suggest that antimalarial drugs may cause epileptic seizures as an adverse reaction in susceptible individuals. Epileptic patients and others with a low seizure threshold appear particularly prone. Antimalarial drugs, particularly chloroquine and mefloquine, should be used
Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV).
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OBJECTIVE
To examine the predictors of time-to-seizure occurrence and their impact on damage accrual and mortality in LUMINA, a multiethnic (Hispanic, African American and Caucasian) cohort of patients with systemic lupus erythematosus.
METHODS
Seizures were defined as per the American College of
Mefloquine-induced grand mal seizure in tubercular meningitis.
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Mefloquine represents a promising antimalarial drug against Plasmodium falciparum. It has been related to an increase in seizure frequency in epileptic patients and should not be administered to patients with a history of convulsions, epilepsy in first degree relatives, or serious psychiatric
Clinical features and management of poisoning due to antimalarial drugs.
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The toxicities of antimalarial drugs vary because of the differences in the chemical structures of these compounds. Quinine, the oldest antimalarial, has been used for 300 years. Of the 200 to 300 compounds synthesised since the first synthetic antimalarial, primaquine in 1926, 15 to 20 are
General Pharmacology of Artesunate, a Commonly used Antimalarial Drug:Effects on Central Nervous, Cardiovascular, and Respiratory System.
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Artesunate, a semi-synthetic derivative of artemisinin, is used primarily as a treatment for malaria. Its effects on the central nervous system, general behavior, and cardiovascular, respiratory, and other organ systems were studied using mice, rats, guinea pigs, and dogs. Artesunate was
Antiepileptic effects of quinine in the pentylenetetrazole model of seizure.
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Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole
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