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broad bean/antineoplásico
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Carboxymethylcellulose improves the antimutagenic activity of sodium selenite against maleic hydrazide in Vicia faba seedlings.
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In this study the genotoxic effects induced by a treatment with different doses of sodium selenite in Vicia faba seedlings were evaluated with or without the addition of carboxymethylcellulose. A further objective of this study was to verify whether the adduct selenite-carboxymethylcellulose was
Hypocholesterolemic and Anticarcinogenic Effect of Vicia faba Protein Hydrolyzates.
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In recent years, the consumption of vegetal-source proteins has been studied to determine their preventing effect on the development of several chronic diseases. The initial purpose of this report was to determine the effect of a hypercholesterolemic diet (HCD) given to mice, alone or with
[A cytogenetic analysis of the antimutagenic action of alpha-tocopherol on spontaneous and radiation-induced chromosomal mutations].
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The antimutagenic effect of alpha-tocopherol at concentrations of 1-10(-5)-1-10 mcC/ml was studied with respect to spontaneous and radiation-induced chromosome mutations in Allium fistulosum L. and Vicia faba L. It is established that at these concentrations alpha-tocopherol exhibits a significant
Effects of five platinum complexes (cis-DDP, trans-DDP, CHIP IV, CBDCA, oxo-Pt) on the induction of sister chromatid exchanges (SCEs) and chromosomal aberrations in Vicia faba root-tip cells.
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In a population of plant meristematic cells of Vicia faba the frequency of sister chromatid exchanges (SCEs), incidence of chromosomal aberrations and mitotic activity of cells was evaluated after short-term treatment (1 h) with antitumour active platinum complexes cis-DDP, CHIP IV, CBDCA, oxo-Pt
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
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Topoisomerases are essential enzymes involved in all processes of DNA metabolism, and their inhibitors have been identified as potential anticancer agents. The present study examined the effect of nine polyphenolic compounds derived from parts of two unique varieties of the Leguminosae, Vicia faba
Inhibitory effect of cheese and some food constituents on mutagenicity generated in Vicia faba after treatment with nitrite.
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The inhibitory potential of various food constituents on the mutagenicity generated in fava beans after treatment with nitrite has been investigated. Cheese was able to inhibit this direct-acting mutagenicity. The antimutagenic factor was not extractable from cheese; solvents of different polarity
Influence of soil characteristics on the clastogenic activity of maleic hydrazide in root tips of Vicia faba.
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The clastogenic activity of the herbicide maleic hydrazide (MH) in Vicia faba seedlings grown in different soils was studied. In the first series of experiments the seedlings were treated with MH in nine soils of different selected properties. The second experimental protocol provided for a growth
[Antimutagenic activity of Armoracia rusticana, Zea mays and Ficus carica plant extracts and their mixture].
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Antimutagenic action of plant extracts of Armoracia rusticana, Ficus carica, Zea mays and their mixture on environmental xenobiotics has been investigated. The plant extracts and their mixture decreased the level of mutations induced by N-metil-N'-nitro-N-nitrozoguanidin (MNNG) in Vicia faba cells,
Long-term feeding of field bean protein containing protease inhibitors suppresses virus-induced mammary tumors in mice.
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Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different
Field bean protease inhibitor mitigates the sister-chromatid exchanges induced by bromoform and depresses the spontaneous sister-chromatid exchange frequency of human lymphocytes in vitro.
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The mutagenicity of a trihalomethane-bromoform (CHBr3)-was assessed by the in vitro sister-chromatid exchange (SCE) assay using human peripheral blood lymphocytes. CHBr3 was found to induce SCEs significantly in a dose-dependent manner. When the cells were exposed to 600 ng CHBr3/ml of the medium,
[Antimutagenic activity of plant extracts from Armoracia rusticana, Ficus carica and Zea mays and peroxidase in eukaryotic cells].
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Antimutagene activity and high efficiency of antimutagene action of plant extracts from horseradish roots (Armoracia rusticana), fig brunches (Ficus carica) and mays seedlings (Zea mays) and their ability to decrease the frequency of spontaneous and induced by gamma-rays chromosome aberrations in
[Genetic effects of root extracts of Glycyrrhiza glabra L. on different test-systems].
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The antimutagenic and geroprotective activities of root extracts of Glycyrrhiza glabra have been demonstrated both on plant test systems--Allium fistulosum L., Allium cepa L., Vicia faba L. and on animals--Vistar rats. The possibilities of the mobilization of Glycyrrhiza glabra root extracts as
Do cancer cells in human and meristematic cells in plant exhibit similar responses toward plant extracts with cytotoxic activities?
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We examined the effect of water extracts of Persea americana fruit, and of the leaves of Tabernamontana divericata, Nerium oleander and Annona cherimolia (positive control) on Vicia faba root cells. We had confirmed in our previously published data the cytotoxicity of these plant extracts on four
The role of various food products in the formation of N-nitroso compounds under acidic conditions.
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The effect of lettuce cultivars on the nitrosation rate of proline was investigated. The lettuce was analysed for the presence of phenolic compounds. Lettuce and/or fish was incubated with nitrite under acidic conditions, and the incubation mixtures were investigated for the presence of N-nitroso
Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent.
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Naturally occurring polysaccharides isolated from the yeasts are the substances with versatile intriguing biomodulatory activities. One of the novel derivatives prepared from the (1 --> 3)-beta-D-glucan isolated from the cell walls of baker's yeast Saccharomyces cerevisiae is sulfoethyl glucan
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