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Triple reuptake inhibitors ("broad spectrum" antidepressants).

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The majority of antidepressants in current use inhibit the uptake of serotonin and/or norepinephrine. Drugs inhibiting the uptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) may offer therapeutic advantages compared to single and/or dual reuptake inhibitors. This review

Trazodone: a novel, broad-spectrum antidepressant.

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"Broad spectrum" antidepressants: is more better for the treatment of depression?

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The majority of antidepressants in current use selectively inhibit the reuptake of serotonin and/or norepinephrine. "Broad spectrum" antidepressants are compounds that inhibit the reuptake of norepinephrine, serotonin and dopamine, the three biogenic amines most closely linked to depression. The

Extended-release bupropion: an antidepressant with a broad spectrum of therapeutic activity?

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Bupropion, a noradrenaline and dopamine re-uptake inhibitor, has long been indicated for the treatment of depression. Recent studies have demonstrated additional benefits in depression, including: prevention of the recurrence of seasonal affective disorder in depressive subtypes with decreased

Broad-spectrum screening of psychotherapeutic drugs: thiothixene as an antipsychotic and antidepressant.

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The broad spectrum of comorbid depression: implications for treatment.

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There is a high rate of depression in patients with medical or other psychiatric disorders. This comorbid depression is associated with an increased morbidity and mortality from medical illness, poor compliance with treatment, a worsening of somatic symptoms, and often a decrease in functional

Phototherapy with broad spectrum white fluorescent light: a comparative study.

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The principles of photobiology suggest that the antidepressant effect of phototherapy depends on the dose and spectrum of light. We investigated the effect of spectrum by comparing two broad spectrum fluorescent light sources with different spectral distributions. In a crossover design, 11 patients

[Multicenter therapy study with the amitriptyline oxide Equilibrin 60--a broad-spectrum antidepressive agent].

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[Which antidepressant for what patients? St. John's wort: broad application - new mechanism of action].

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SSRIs and SNRIs: broad spectrum of efficacy beyond major depression.

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Originally studied and introduced for the treatment of depression, the selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) have proven effective for a broad range of psychiatric illnesses, including several anxiety disorders, bulimia, and

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

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A series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, alpha-adrenergic, and histamine receptors and for the norepinephrine transporter as well as the ED(50) values

The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug.

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Aprepitant is a selective high-affinity antagonist of human substance P (SP)/Neurokinin-1 (NK-1) receptors. Until now this drug has been used as anxiolytic, antidepressant and antiemetic. It has been demonstrated that SP induces cell proliferation and NK-1 receptor antagonists different to

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models.

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BACKGROUND Serotonin (5-HT)(2C) receptors are implicated in the control of mood, and their blockade is of potential interest for the management of anxiodepressive states. OBJECTIVE Herein, we characterized the in vitro and in vivo pharmacological profile of the novel benzourea derivative,

Effectiveness of venlafaxine treatment in a broad spectrum of depressed patients: a meta-analysis.

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The effectiveness of the novel antidepressant venlafaxine was assessed in various subpopulations of depressed patients. Data from six comparable placebo-controlled, double-blind studies were pooled and analyzed (venlafaxine, n = 930; placebo, n = 500). Outcome variables were the Hamilton Rating

[A drug with the broad spectrum of pharmacological activity for the treatment of complex neuropsychic disorders].

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The influence of a pyrrolo-pyrazine derivative AL-613 (synthesized at the Zakusov Institute of Pharmacology) on the behavior of outbred male albino rats has been studied on various experimental models. It was established that AL-613 produces anxiolytic action in a conflict situation model and

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