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broad/antineoplásico
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A broad anticancer effect of aspirin?
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Broad-acting HPV vaccines explored to fight cancer.
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Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.
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On the basis of the potent biological activity of cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from D-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor
Belinostat: a new broad acting antineoplastic histone deacetylase inhibitor.
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Belinostat is a potent hydroxamate-type histone deacetylase inhibitor with a broad antineoplastic activity in a spectrum of preclinical tumor models and with demonstrated clinical efficacy in the still very early clinical trial program. Belinostat has been relatively well tolerated following both
Cardiac glycosides are broad-spectrum senolytics.
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Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that selectively
Broad-Spectrum Anti-Cancer Activity of O-Arylated Diazeniumdiolates.
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O(2)-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) and O(2)-{2,4-dinitro-5-[4-(N-methylamino)be nzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate (PABA/NO) are O(2)-arylated diazeniumdiolates that have shown promising in vivo activity in a
Prediction of broad spectrum resistance of tumors towards anticancer drugs.
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OBJECTIVE
Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult to predict the individual response of tumors. The concept of individualized therapy aims
Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent.
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This work presents a highly efficient, broad spectrum and self-delivery anticancer agent, which is the hyperbranched polydiselenide (HPSe) consisting of alternative hydrophobic diselenide groups and hydrophilic phosphate segments in the backbone framework. The data of systematic evaluations
The Anticancer Peptide TAT-RasGAP317-326 Exerts Broad Antimicrobial Activity.
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Antibiotic resistance has become a major health issue. Nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. Therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. We have
Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate.
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Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol modulates different critical pathways.
Largazole: from discovery to broad-spectrum therapy.
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The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting
Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity.
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Previously, we discovered a novel class of salicylhydrazide compounds with remarkable activity in hormone-dependent and -independent human cancer cells. We then designed and synthesized numerous analogues. Among these analogues, a quinoxalinhydrazide compound, SC144, exhibited desirable
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity.
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Among the 25 bis(cyclopentadienyl)vanadium(IV) and 14 oxovanadium(IV) compounds synthesised and evaluated for anticancer activity, bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) (metvan) was identified as the most promising multitargeted anticancer vanadium complex with
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
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The stress-induced HSP70 is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in nontransformed cells, but is greatly overexpressed in tumor cells. Silencing HSP70 is uniformly
Ring-expanded ("Fat") nucleosides as broad-spectrum anticancer and antiviral agents.
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Ring-expanded (ldauo;fat") nucleosides (RENs) described in this review are analogues of purine nucleosides containing a 5:7-fused imidazodiazepine or imidazotriazepine ring system. They are both of natural and synthetic origin, and are of chemical, biochemical, biophysical, as well as medicinal
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