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Broad-spectrum cardioprotection with adenosine.

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Ischemia-reperfusion results in contractile dysfunction, necrosis, and vascular injury. This postischemic injury is mediated in part by superoxide radical production, neutrophils, dysfunction to ionic pumps, and edema formation. Adenosine is an autacoid released tonically by myocytes, endothelium,

[Differential diagnosis of tachycardia with a broad QRS-complex].

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BACKGROUND The electrocardiographic (ECG) differential diagnosis of tachycardia with a broad QRS complex (BCT) represents a challenge for physicians but is important for adequate treatment and risk evaluation. Differentiated algorithms have been established and can increase the specificity of the

Endovascular mechanical clot retrieval in a broad ischemic stroke cohort.

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OBJECTIVE Our aim was to describe an expanded experience with endovascular mechanical embolectomy in a broad group of patients, including those not meeting entry criteria for the MERCI multicenter trials. METHODS We performed an analysis of all patients with ischemic stroke treated with the Merci

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

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OBJECTIVE Expression of numerous chemokine-related genes is increased in the brain after ischemic stroke. Here, we tested whether post-stroke administration of a chemokine-binding protein (CBP), derived from the parapoxvirus bovine papular stomatitis virus, might reduce infiltration of leukocytes

Multivariate analysis to simplify the differential diagnosis of broad complex tachycardia.

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Univariate analysis has identified several criteria that aid the differential diagnosis of broad complex tachycardia. In this study of 102 consecutive patients multivariate analysis was performed to identify which of 15 clinical and 11 electrocardiographic variables were independent predictors of

Chest pain in the emergency department: the broad spectrum of causes.

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We performed a prospective study to describe the broad spectrum of causes of chest pain in patients presenting to the emergency department and to compare the diagnoses in referred patients, self-referred patients and patients rushed in by ambulance. The final diagnosis in a consecutive case series

[Acute promyelocytic leukemia (APL) resulting in broad cerebral infarction during all-trans retinoic acid (ATRA) treatment].

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A 27-year-old woman visited Kanto Teishin Hospital complaining of fever and petechiae in September, 1992. Her fetus had suddenly died in the uterus two weeks before (in the sixth month of pregnancy). Total white blood cell (WBC) count was 3.2 x 10(3)/microliters with 80% promyelocytes. Bone marrow

Effects of coronary stents on cardiovascular outcomes in broad-based clinical practice.

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BACKGROUND Although stents have been shown to reduce the need for repeated percutaneous coronary intervention (PCI) in randomized trials, the effects of stents in broad-based, diverse clinical practice have not been well studied, nor has their effect on subsequent myocardial infarction or cardiac

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.

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Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, including reversal of inflammation-mediated loss of

Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity.

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BACKGROUND We investigated the effects of asialoerythropoietin (asialoEPO), a nonerythrogenic erythropoietin derivative, on 3 murine models of heart failure with different etiologies. RESULTS Doxorubicin (15 mg/kg) induced heart failure within 2 weeks (toxic cardiomyopathy). Treatment with asialoEPO

Severity of dementia correlates with loss of broad-band visual cortical responses.

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We have shown that the response to flash stimulation of the occipital electroencephalogram (EEG) in Alzheimer disease (AD) patients is smaller than in normal subjects. To ascertain whether this is a specific feature of AD or a nonspecific effect of dementia, we investigated in AD and multi-infarct

The use of echocardiographic colour kinetic wall motion to differentiate broad complex tachycardia.

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Discrimination between supraventricular tachycardia (SVT) with aberrant conduction from ventricular tachycardia (VT) is vital for the safe and effective management of both conditions. Electrocardiographic algorithms for the differentiation of broad complex tachycardia are complex and difficult to

Coronary stenting without predilatation in a broad spectrum of clinical and angiographic situations.

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BACKGROUND Direct coronary stenting without balloon predilatation has the potential benefits of a reduced risk of extended dissections, reduced fluoroscopy exposure, reduced procedural time, and potential cost savings. With the availability of superior stents and delivery systems, we review our

Isolated cardiac involvement of B-cell acute lymphoblastic leukemia mimicking acute myocardial infarction with persistent broad ST-segment elevation.

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Signal averaging of the electrocardiogram in the remote differential diagnosis of broad complex tachycardias.

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The diagnosis of the origin of a broad complex tachycardia may be difficult, especially in the absence of a 12-lead electrocardiogram of the tachycardia. This study investigates the value of signal averaging in the differential diagnosis of broad complex tachycardia. Signal averaging during sinus

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