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Dissolution of cystine stones by irrigated tiopronin solution.
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A new method involving the introduction of tiopronin solution directly into the renal pelvis or bladder has been developed for the treatment of cystine stones. Therapeutic irrigation by tiopronin solution was done in 4 cases of residual cystine kidney stones using a nephrostomy tube, and in an
Fatigue of kidney stones with heterogeneous microstructure subjected to shock-wave lithotripsy.
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In this article a theoretical framework is developed for the mechanics of kidney stones with an isotropic, random microstructure--such as those comprised of cystine or struvite. The approach is based on a micromechanical description of kidney stones comprised of crystals in a binding matrix. Stress
N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
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The production of reactive oxygen species in skeletal muscle is linked with muscle fatigue. This study investigated the effects of the antioxidant compound N-acetylcysteine (NAC) on muscle cysteine, cystine, and glutathione and on time to fatigue during prolonged, submaximal exercise in endurance
[A comparative study of 6 kinds of nourishing glue].
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The experimental results have shown that all six kinds of glue have a common protein zone, but only the pipefish glue has a band on the negative electrode side. They are all rich in amino acids. Oxhide glue has the highest content of amino acids, total Ajiao has the highest content of essential
Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
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The combination of abnormally low plasma cystine and glutamine levels, low natural killer (NK) cell activity, skeletal muscle wasting or muscle fatigue, and increased rates of urea production defines a complex of abnormalities that is tentatively called "low CG syndrome." These symptoms are found in
Serum amino acid concentrations in nine athletes before and after the 1993 Colmar ultra triathlon.
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The amino acid imbalance hypothesis should explain the fatigue originating in the brain during sustained exercise or over-training as a branched-chain (BCAA)/aromatic amino acids (AAA) imbalance with increased brain tryptophan uptake and 5-hydroxytryptamine synthesis. The serum amino acid profile
Phase I trial of imexon in patients with advanced malignancy.
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OBJECTIVE
Imexon, a pro-oxidant small molecule, has antitumor activity in preclinical models. The drug induces apoptosis through accumulation of reactive oxygen species. The purpose of this trial was to define the maximum-tolerated dose (MTD), toxicities, pharmacokinetics, and pharmacodynamics of
Amino acid metabolism in uremia.
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The uremic syndrome is multifactorial, and affects most tissues and organs. Disturbances in protein and amino acid metabolism may play important roles, especially in chronic uremia, either directly or by production of toxic metabolites, with resultant negative nitrogen (N) balance, muscle wasting,
Role of cysteine and glutathione in signal transduction, immunopathology and cachexia.
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Abnormally low plasma cystine levels have been found in the late asymptomatic stage of HIV infection and several other diseases associated with progressive loss of skeletal muscle mass. The phenomenon is commonly associated with a low NK cell activity, skeletal muscle wasting or muscle fatigue and
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