Depsipeptides represented by the formula (1): ##STR1##(wherein:R.sub.1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R.sub.2 is --A--B, --A--B--W, --A--B--W--D or --A--B--W--D--E, R.sub.3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, --Z, --Z--G or --Z--G--J, the above A, B, D, E, G and J independently each other are a residue of an amino acid selected from alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine and the like or an N--(C.sub.1 -C.sub.4) alkyl derivative of these amino acid residues; the above W and Z independently each other are a residue of an amino acid selected from aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine) or pharmacologically acceptable salts thereof.The depsipeptides have an activity of promoting the production of apolipoprotein E and are useful as a therapeutic agent for neurologic damages, especially for dementia, and further as a therapeutic agent for hyperlipemia.

Nisshin Flour Milling Co., Ltd.

Depsipeptides and drugs containing the same as the active ingredient

8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid has a protein tyrosine phosphatase 1B (PTP1B) inhibitory action, an Akt activating action, a GSK-3.beta. phosphorylation promoting action, and a suppressive action on .tau. protein phosphorylation induced by A.beta..sub.1-42, and is useful as a therapeutic drug for Alzheimer-type dementia, an antidepressant and/or an anti-aging drug.

dementia/tyrosine

Depsipeptides and drugs containing the same as the active ingredient

Inhibitor of .tau. protein phosphorylation

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