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diabetes mellitus type 2/prolina
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14 resultados
L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hy- droxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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FIELD OF THE INVENTION
The present invention is directed to L-proline and citric acid co-crystals of (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylp- henyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, pharmaceutical compositions containing said co-crystals and their
D-proline derivatives
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BACKGROUND OF THE INVENTION
1. Field
The invention relates to D-prolines and their use in treating diseases associated with amyloidosis.
2. Description
The compounds (R)-1-[(R)- -3-mercapto-2-methyl-propionyl]-pyrrolidine-2-carboxylic acid and
D-proline derivatives
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BACKGROUND OF THE INVENTION
1. Field
The invention relates to D-prolines and their use in treating diseases associated with amyloidosis.
2. Description
The compounds (R)-1-[(R)-3-mercapto-2-methyl-propionyl]-pyrrolidine-2-carboxylic acid and
D-proline derivatives
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BACKGROUND OF THE INVENTION
1. Field
The invention relates to D-prolines and their use in treating diseases associated with amyloidosis.
2. Description
The compounds (R)-1-[(R)-3-mercapto-2-methyl-propionyl]-pyrrolidine-2-carboxylic acid and
D-proline derivatives
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BACKGROUND OF THE INVENTION
1. Field
The invention relates to D-prolines and their use in treating diseases associated with amyloidosis.
2. Description
The compounds (R)-1-[(R)- -3-mercapto-2-methyl-propionyl]-pyrrolidine-2-carboxylic acid and
Prodrug of 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
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FIELD OF THE INVENTION
The present invention relates to the novel compound (2R,2'R)-Bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate), pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders
Prodrug of 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
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This application is a .sctn.371 of International Application No. PCT/EP2015/058998, filed 27 Apr. 2015, which claims priority of GB 1407506.3, filed 29 Apr. 2014.
FIELD OF THE INVENTION
The present invention relates to the novel compound
Prodrug of 1,1'-(1,6-dioxo -1,6-hexanediyl)bis-D-proline
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FIELD OF THE INVENTION
The present invention relates to the novel compound (2R,2'R)-Bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate), pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders
Prodrug of 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
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FIELD OF THE INVENTION
The present invention relates to the novel compound (2R,2'R)-Bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate), pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders
D-proline derivatives as SAP depleting agent
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FIELD OF THE INVENTION
The present invention relates to the compound (2R,2'R)-bis(((tetrahydro-2H-pyran-4-carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate), pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders wherein depletion
Ertugliflozin co-crystals and process for their preparation
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FIELD OF THE INVENTION
The present invention relates to processes for the preparation of an ertugliflozin-L-pyroglutamic acid (1:1) co-crystal and ertugliflozin-L-proline (1:1) co-crystal. The present invention further relates to an ertugliflozin-L-proline (1:2) co-crystal, processes for its
Multivalent inhibitors of serum amyloid P component
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FIELD OF THE INVENTION
The present invention relates to new glycerol cyclic pyruvate derivatives and their use, in particular in the treatment or prevention of amyloidosis.
BACKGROUND OF THE INVENTION
Human serum amyloid P component (SAP) is a normal plasma protein that has been associated with
Protein hydrolysate enriched in peptides inhibiting DPP-IV and their use
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The present invention relates to a protein hydrolysate enriched in certain peptides, such isolated peptides, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV
Inhibitors of dipeptidyl peptidase IV
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The present invention relates to novel compounds that are inhibitors of post-proline aminopeptidases. The compounds are useful as antiproliferative agents and in the treatment of, inter alia, type 2 diabetes and impaired glucose tolerance.
BACKGROUND
The enzyme dipeptidyl peptidase IV, herein
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