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diabetic nephropathies/obesidad
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Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders
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FIELD OF THE INVENTION
The present invention relates generally to methods and compositions for use in the prevention or treatment of risk factors for cardiovascular diseases such as obesity, metabolic syndrome, diabetes, and vascular and renal disorders. More particularly, the present invention
Morphinan-derivatives for treating diabetes and related disorders
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FIELD OF INVENTION
The invention relates to morphinan-derivatives, pharmaceutical compositions containing such morphinan-derivatives and the use of those morphinan-derivatives and/or compositions for treating diseases and conditions in man and other mammals, either alone or in combination with other
Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
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FIELD OF INVENTION
The present invention relates to a method of making novel dipeptidyl peptidase-IV ("DPP-IV`) inhibitor compounds and a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.
BACKGROUND OF
Benzene compounds
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to benzene compounds, and more particularly, to novel benzene compounds having inhibition activity on acetyl CoA carboxylase ("ACC" hereinafter).
2. Discussion of the Background
It has become clear in recent years
Methods and compositions for the inhibition of fructokinase
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FIELD OF THE INVENTION
The present inventors have identified fructokinase as a key enzyme that drives a host of metabolic conditions characterized by sugar craving, obesity, metabolic syndrome, and renal disease. In particular, isoform specific inhibitors targeting fructokinase C, or both
Lactam compound, a method for producing the same, and a diabetic therapy by administering the same
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a medicinal drug, and in particular, to a novel lactam compound having sugar transport enhancement action and having excellent hypoglycemic action, a preparation method thereof, and a preparation intermediate
Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
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The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled A-1824-US-PCT_SeqList.txt, created Jun. 5, 2015 which is 33 KB size. The information in the electronic format of the Sequence Listing is incorporated herein
Secreted frizzle-related protein 5 (SFRP5) binding proteins
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The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled A-1830-US-PCT_SeqList.txt, created Jun. 5, 2015, which is 45 KB in size. The information in the electronic format of the Sequence Listing is incorporated
Growth differentiation factor 15 (GDF-15) constructs
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jul. 29, 2014, is named A-1850-WO-PCT_SL.txt and is 630,200 bytes in size.
FIELD OF THE
Growth differentiation factor 15 (GDF-15) polypeptides
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SEQUENCE LISTING
The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled A-1682-US-CNT_SeqList.txt, created Jun. 14, 2017, which is 247 KB in size. The information in the electronic format of the Sequence Listing
Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists
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FIELD OF THE INVENTION
The present disclosure relates to the treatment or amelioration of a metabolic disorder, such as type 2 diabetes, elevated glucose levels, elevated insulin levels, obesity, non-alcoholic fatty liver disease, or cardiovascular diseases, using an antigen binding protein specific
Growth differentiation factor 15 (GDF-15) polypeptides
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 28, 2013, is named A1682WOP.txt and is 253,155 bytes in size.
FIELD OF THE INVENTION
The
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
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1. FIELD OF THE INVENTION
The invention relates to cycloalkyl-hydroxyl compounds and pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; compositions comprising a hydroxyl compound or a pharmaceutically acceptable salt, hydrate, solvate, or mixtures thereof; and methods for
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