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ArtículosEnsayos clínicosPatentes
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Effects of a combination of metoprolol and dazmegrel on myocardial infarct size in rats.

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The effects of acute pretreatment with metoprolol, dazmegrel and a combination of these two drugs has been examined on myocardial infarct size in rats. Ischaemic damage was assessed 4 h after coronary artery occlusion in anaesthetized rats and after 48 h of ischaemia in conscious rats. Infarct size

Alpha-glucosidase deficiency and basilar artery aneurysm: report of a sibship.

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Glycogen deposition in vascular smooth muscle has been demonstrated previously in alpha-glucosidase deficiency but has not been clinically significant. Three sons of healthy, nonconsanguineous parents developed progressive proximal muscular weakness secondary to alpha-glucosidase deficiency. Each

Light chain deposition disease of the liver associated with AL-type amyloidosis and severe cholestasis.

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A 67-year-old man with a 3-month history of jaundice presented with hepatomegaly. Laboratory studies revealed abnormal liver tests with raised bilirubin. Renal function was normal. Endoscopic retrograde cholangiopancreatography revealed normal extrahepatic bile ducts. Liver biopsy showed severe

Splenic pathology in thrombotic thrombocytopenic purpura.

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To determine splenic pathology in thrombotic thrombocytopenic purpura (TTP), 10 spleens and two accessory spleens were studied. The eight women and two men ranged from 20 to 66 years of age (mean age, 39 years). Three spleens were enlarged. Thrombi were noted in arteries and arterioles in nine

Lipomembranous fat necrosis in three cases of testicular torsion.

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OBJECTIVE To describe for the first time a lesion termed lipomembranous fat necrosis (LFN) in three patients with spermatic cord torsion. RESULTS We reviewed 386 testes and their epididymides and spermatic cords which had been removed for testicular infarction. For the three cases showing LFN, a

Granular cell change in astrocytic tumors.

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Intracerebral granular cell neoplasms are uncommon. We report five hemispheric astrocytomas, all of which showed the distinctive features of granular cell change, being composed exclusively or predominantly of rounded cells with coarse granular eosinophilic cytoplasm and eccentrically placed nuclei.

[Myocardial revascularization with arterial grafts alone: our experience].

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Bilateral internal mammary artery (IMA) grafting is recognized as a preferred method of myocardial revascularization. However, for multivessel coronary artery disease, saphenous veins often have to be added to complete myocardial revascularization. The right gastroepiploic artery (rGEA) has been

The morphological spectrum of lymphadenopathy in HIV infected patients.

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OBJECTIVE To study the histological spectrum of lymphadenopathy in human immunodeficiency virus (HIV) infected Thai patients. METHODS Lymph nodes from 55 HIV infected patients were accessioned over a 19 month period in two pathology laboratories in Bangkok, Thailand. These were examined with H&E,

An experimental evaluation of staining techniques for the detection of early ischaemic injury to the myocardium.

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A series of experimental infarcts of the posterior papillary muscle of the canine heart was used to assess the value of 6 special stains in the histological detection of early myocardial infarction. The infarcts were of 5-720 min duration and were compared not only with normal control myocardium but
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