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fissure in ano/cefalea
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Nitroglycerin ointment for anal fissures: effective treatment or just a headache?
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OBJECTIVE
Topical nitrates have been shown to cause nitric oxide-mediated relaxation of the internal anal sphincter. Previous reports have suggested initial efficacy in the treatment of anal fissures. The aim of this study was to assess the longer-term usefulness of this
Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches?
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BACKGROUND
Application of nitroglycerin (glyceryl trinitrate) ointment with perianal administration is a widely used treatment for chronic anal fissure. However, headache occurs after application in 20% to 70% patients and leads to withdrawal in 10% of patients.
OBJECTIVE
The aim of the study was to
Comparison of Fissure Healing and The Incidence of Headache Among the Patients Treated with Endo- and Perianal Application of 0.2% Glyceryl Trinitrate for Chronic Anal Fissure.
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Chronic anal fissure is associated with significant morbidity and reduction in quality of life mostly in young healthy adults. Glyceryl Trinitrate, a most commonly used agent for treatment, is associated with incidence of headache causing discontinuation of treatment. There is belief that endoanal
Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial.
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OBJECTIVE
Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence. Reversible chemical sphincterotomy may be achieved by anal application of glyceryl trinitrate ointment (nitric oxide donor), which has been reported to heal the majority of patients with
Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches? Retraction.
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Headaches in the treatment of anal fissure.
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Case report: herpes meningitis complicating genital herpes presenting as anal fissure.
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A 33-year-old woman presented with stabbing perianal pain and intermittent headache and photophobia. Examination revealed atypical multiple perianal fissures with non-specific neurological findings. Polymerase chain reaction of the perianal swab and cerebrospinal fluid examination confirmed the
Comparison of topical nifedipine with oral nifedipine for treatment of anal fissure: a randomized controlled trial.
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BACKGROUND
Medical sphincterotomy has gained popularity as a treatment for anal fissure. Calcium channel blockers in topical forms could also be appropriate with low adverse effects.
OBJECTIVE
This was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment
Effectiveness of 0.2% Glyceryl Trinitrate and 0.5% Nifedipine in the Treatment of Chronic Anal Fissure.
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BACKGROUND
Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal. This study aimed to assess the efficacy of Glyceryl Trinitrate and Nifedipine in the treatment of chronic anal fissure.
METHODS
Ninety
Glyceryl trinitrate treatment of chronic fissure in ano: one year's experience with 0.5% GTN paste.
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OBJECTIVE
Assessment of the efficacy of topical 0.5% glyceryl trinitrate (GTN) paste in the treatment of chronic fissures in ano.
METHODS
Forty-five patients were treated with 0.5% GTN paste and reviewed at 3, 6 and 12 weeks to assess symptoms, side effects and fissure healing.
RESULTS
At 6 weeks,
Treatment of anal fissure with glyceryl trinitrate in patients referred for surgical management.
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BACKGROUND
A number of recent studies indicate that anal fissure may be treated by applying glyceryl trinitrate (GTN) ointment. The present study aims to determine the effectiveness and patient acceptability of GTN treatment for patients referred to a consultant surgeon.
METHODS
A prospective study
Lateral internal sphincterotomy versus 0.25 % isosorbide dinitrate ointment for chronic anal fissures: a prospective randomized controlled trial.
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OBJECTIVE
To compare the healing properties of lateral internal sphincterotomy (LIS) and isosorbide dinitrate (ISDN) ointment for chronic anal fissure.
METHODS
Patients with a chronic anal fissure were randomly assigned to a group treated with ISDN ointment (n = 105) or a group treated with LIS (n =
Morbidity associated with treatment of chronic anal fissure.
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OBJECTIVE
To assess the effectiveness of different modes of treatment of chronic anal fissure as regards improvement of symptoms and complications.
METHODS
This prospective study included 129 consecutive patients with chronic anal fissures presented to the Surgical Outpatients' Department of Islam
Isosorbide dinitrate in the treatment of anal fissure: a randomised, prospective, double blind, placebo-controlled trial.
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OBJECTIVE
To assess the efficacy of isosorbide dinitrate in healing anal fissures.
METHODS
Randomised, prospective, double blind, placebo controlled trial.
METHODS
Teaching hospital, The Netherlands.
METHODS
37 consecutive subjects with anal fissure diagnosed in the surgical outpatient
Disappointing results of glyceryl trinitrate ointment in the treatment of chronic fissure-in-ano in a district general hospital.
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OBJECTIVE
The recent introduction of glyceryl trinitrate ointment (GTN) has greatly changed the management of chronic fissure-in-ano. We have investigated the results obtained from this new treatment and the consequent alterations to surgical practice.
METHODS
All patients who presented with chronic
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