Pancreatic Necrosis

serum mitochondrial DNA will be measured using RT-PCR within first 72 hours of symptoms of acute pancreatitis

serum mitochondrial DNA

Predicting Pancreatic Necrosis Using mitDNA

Study of Plasma mitDNA in Predicting Pancreatic Necrosis in Acute Pancreatitis

level of serum mitochondrial DNA in severe acute pancreatitis

Soha Mohammad Nageb

spechialist

Assiut University

Receives Lactated Ringers solution at 3cc/kg/hr following an initial 20cc/kg bolus.

Receives Lactated Ringers solution at 1.5cc/kg/hr following an initial 10cc/kg bolus.

Pancreatitis

Receives 20cc/kg bolus and 3cc/kg/hr thereafter.

Aggressive Hydration

Receives 10cc/kg bolus and 1.5cc/kg/hr thereafter.

Moderate Hydration

Los Angeles County Hospital

Moderate Versus Aggressive Fluids for Acute Pancreatitis

Moderate Versus Aggressive Fluid Therapy in Patient With Mild to Moderate Acute Pancratitis

Decreased hematocrit, BUN, Cr compared to time zero, decreased epigastric pain, and ability to tolerate PO's.

Time required to reach clinical improvement (as defined in primary outcome measure)

Patients initally in the moderate hydration arm who have an increase in BUN, CR, Hematocrit, or epigastric pain and thus are crossed over to the aggressive hydration arm.

SIRS will be defined based on having 2 out of 4 possible criterion. A) heart rate >90, respiratory rate >20, Temperature greater than 100.4 degrees farenheit or less than 96.8 degrees farenheit. White blood count >10 of <4.

Severe pancreatitis will be defined if 1 of the following is present; pancreatic necrosis (>30%) or abscess, blood pressure <90mmHg, oxygen saturation <90%, Cr >2mg/dl after 12 hours of resuscitation, >10 days hospitalization, or pseudocyst. Pseudocyst is deefined as a peripancreatic fluid collection which does not resorb within 4-8 weeks.

Physical exam findings of pitting edema, ascites, anasacra, pulmonary edema, or dyspnea.

gallstones/protease

Predicting Pancreatic Necrosis Using mitDNA

Moderate Versus Aggressive Fluids for Acute Pancreatitis

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