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glutathione reductase/hypoxia
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Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice.
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OBJECTIVE
Sleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent
Purification and properties of glutathione reductase from liver of the anoxia-tolerant turtle, Trachemys scripta elegans.
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Glutathione reductase (GR) is a homodimeric flavoprotein that catalyzes the reduction of oxidized glutathione (GSSG) using NADPH as a cofactor. The enzyme is a major component of cellular defense mechanisms against oxidative injury. In this study, GR was purified from the liver of the
Regulation of thiols in the brain. I. Concentrations of thiols and glutathione reductase activity in different parts of the rat brain during hypoxia.
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[ACTIVITY OF GLUTATHIONE REDUCTASE IN THE BLOOD OF RATS UNDER NORMAL CONDITIONS AND IN OXYGEN DEFICIENCY].
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Blueberry extracts protect testis from hypobaric hypoxia induced oxidative stress in rats.
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Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase
Glutathione reductase activity and chilling tolerance are induced by a hydroxylamine derivative BRX-156 in maize and soybean.
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The possible contribution of antioxidants in the improvement of stress tolerance induced by the hydroxylamine derivative BRX-156 was studied in two thermophilic crops, soybean (Glycine max (L.) Merr.) and maize (Zea mays L.) both during germination and at the seedling stage. The most effective
EFFECT OF POMEGRANATE (Punica granatum L) JUICE ON CHANGES IN TISSUE GLUTATHIONE LEVELS OF RATS EXPOSED TO HIGH ALTITUDE HYPOXIA.
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Oxidative stress due to excessive production of free radicals in living organisms during exposure to hypobaric hypoxia is well documented. In search of a suitable antioxidant from natural sources, in the present study effect of pomegranate (Punica granatum, family Punicaceae) juice (PG) was
Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture.
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Hippocampus has received a considerable attention in the recent past due to its role in a number of important functions such as learning and memory. The effect of hypoxia on neuronal cell injury especially on hippocampal cells is not well known. The aim of the present study was to characterize the
Effect of intermittent hypoxia on pro- and antioxidant balance in rat heart during high-intensity chronic exercise.
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The purpose of the present study was to elucidate the influence of sessions of intermittent hypoxic training (IHT) alone and in combination with high-intensity chronic exercise on lipid peroxidation and antioxidative defense system in rat heart. High-intensity chronic exercise was performed as
Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia.
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To address the influence of oxidative stress and defense capacities in the effects of transient hypoxia in the immature brain, the time course of reactive oxygen species generation was monitored by flow cytometry using dihydrorhodamine 123 and 2',7'-dichlorofluorescein-diacetate in cultured neurons
[The antioxidant action of taurine in acute hypoxic hypoxia].
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It was found that preliminary treatment by amino acid taurine protected rats from lipid peroxidation intensification (expressed in terms of malondialdehyde and conjugated dienes contents) in the liver, brain and heart under acute severe normobaric hypoxic hypoxia. The mechanisms of the antioxidant
S-nitrosoglutathione and hypoxia-inducible factor-1 confer chemoresistance against carbamoylating cytotoxicity of BCNU in rat C6 glioma cells.
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BCNU (1,3-bis[2-chloroethyl]-1-nitrosourea) is the mainstay in glioblastoma multiform chemotherapy with only minimal effects. BCNU may kill tumor cells via carbamoylating cytotoxicity, which irreversibly inhibits glutathione reductase with resultant accumulation of oxidized form of glutathione
Anti-oxidant enzymes in fetal guinea pig brain during development and the effect of maternal hypoxia.
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The development of the anti-oxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase was studied in the fetal guinea pig brain at 30, 35, 40, 45, 50, 55, and 60 days of gestation. The activities of these enzymes remained
Effect of propofol on oxidative stress in an in vitro model of anoxia-reoxygenation in the rat brain.
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Propofol, an intravenous anaesthetic, is similar in chemical structure to the active nucleus of antioxidant substances such as alpha-tocopherol (vitamin E). The present study was designed to test whether propofol had antioxidant effects in an in vitro model of anoxia-reoxygenation in slices of rat
Effects of L-arginine and L-carnitine in hypoxia/reoxygenation-induced intestinal injury.
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BACKGROUND
This study was designed to show the role of oxidative stress, nitric oxide and glutathione-related antioxidant enzymes in hypoxia/reoxygenation (H/R)-induced intestinal injury model in mice and to evaluate the potential benefits of arginine and carnitine supplementation.
METHODS
A total
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