hydronephrosis/hypoxia

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Hydronephrosis promotes expression of hypoxia-inducible factor 1 alpha.

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BACKGROUND Obstructive uropathy is argued to involve an ischemia-type tissue injury. Further, hypoxia-inducible factor 1 alpha (HIF-1 alpha) constitutes a nuclear transcription factor normally upregulated under hypoxic conditions. We hypothesized that HIF-1 alpha is expressed in the hydronephrotic

[Bilateral hydronephrosis and erythrocytosis].

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A 36-year-old woman who developed extreme erythrocytosis following partial correction of severe bilateral hydronephrosis by bilateral ureterolithotomy is presented. Hydronephrosis appears to stimulate renal synthesis and release of erythropoietin. The mechanism could involve increase in medullary

The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells

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Congenital hydronephrosis caused by ureteropelvic junction obstruction (UPJO) eventually leads to renal interstitial fibrosis and atrophy, after a series of pathophysiological problems. Renal repair after injury depends on renal stem cells. This study aimed to determine the expression of renal stem

Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway.

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Secondary polycythemia with increased production of erythropoietin (EPO) is known to occur in kidney diseases such as hydronephrosis and cystic disease, but the mechanism remains unclear. We report an 18-year-old female with isolated renal relapse of acute lymphoblastic leukemia accompanied by

[Microhemodynamics of the renal cortex in the experimental hydronephrosis].

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The authors have studied the influence of unilateral urethral occlusion in the development of microhemomicrocirculatory disorders in renal cortex both on side of the damage and on the opposite side. It was shown, that the degree of hemomicrocirculatory disorders on occlusion side depends on duration

Polycythemia following renal transplantation.

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Among 60 renal allograft recipients, 3 patients were found to be polycythemic with hematocrits greater than 55 and were studied extensively with various hematologic and radiographic procedures. None of the patients showed evidence of erythropoietin-secreting malignancies, renal cysts,

Potential role for the nuclear transcription factor NF-kappa B in the pathogenesis of ureteropelvic junction obstruction.

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OBJECTIVE In an effort to better understand the pathophysiology of ureteropelvic junction (UPJ) obstruction and to determine possible predisposing factors for endopyelotomy failures, we compared the activation of the nuclear factor NF-kappa B and proinflammatory cytokines in patients who failed

Lowered plasma erythropoietin in hypoxic rats with kidney tubule lesions.

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The role of the kidney tubules in the renal formation of erythropoietin is incompletely understood. Therefore, the capability to produce erythropoietin in response to hypoxia was studied in rats with tubular lesions. Nephron damage was induced in two different ways. First, rats were treated with the

[Case of successfully treated acute respiratory distress syndrome complicated by ureteral stones].

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We report a case of acute respiratory distress syndrome caused by uropathogenic Escherichia coli induced sepsis and treated successfully. A 56-year-old women admitted for high-fever, dyspnea, and disturbance of consciousness on September 11, 2006, was found in chest computed tomography (CT) on

A case report of endorectal displacement of a right ureteral stent following radiochemotherapy and Bevacizumab.

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The angiogenesis inhibitor monoclonal antibody Bevacizumab is presently the standard treatment for numerous neoplasms but particular toxicities are emerging, such as hypertension, haemorrhage, thromboembolism, gastrointestinal perforation, fistulae, and delayed wound healing. The

Surgically correctable hypertension of renal origin in childhood.

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Since 1960, 22 children were treated for surgically correctable hypertension or renal origin. The series included two children with tumors, two with hydronephrosis from ureteropelvic junction obstruction, nine in whom one kidney was atrophic, and nine with renal artery narrowing from fibromuscular

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