hypercholesterolemia/phosphatase

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Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.

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OBJECTIVE Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity

Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition.

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The study has been designed to investigate downstream mechanisms in the PTPase inhibition mediated attenuation of diabetes mellitus and hypercholesterolemia-induced vascular endothelial dysfunction. Diabetes mellitus was induced in rats using streptozotocin (55 mg/kg, i.v. once), while

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

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In liver, glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate, the final step in the gluconeogenic and glycogenolytic pathways. Mutations in the glucose-6-phosphatase catalytic subunit (G6Pase) give rise to glycogen storage disease (GSD)

Increased bone turnover in patients with hypercholesterolemia.

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Osteoporosis has been linked with arteriosclerotic vascular diseases, suggesting that hypercholesterolemia or dyslipidemia may be a common pathogenetic factor underlying these diseases. However, little is known about the relationship between osteoporosis and hypercholesterolemia. The purpose of this

Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia.

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OBJECTIVE No consensus has been reached whether clinical use of statins has beneficial effects on bone health, partly due to lower statin concentrations because of first-pass metabolism by the liver. We thus evaluated the effects of pitavastatin, which does not undergo first-pass metabolism, on bone

Why high cholesterol levels help hematological malignancies: role of nuclear lipid microdomains.

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BACKGROUND Diet and obesity are recognized in the scientific literature as important risk factors for cancer development and progression. Hypercholesterolemia facilitates lymphoma lymphoblastic cell growth and in time turns in hypocholesterolemia that is a sign of tumour progression. The present

Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase.

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Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with two catalytic domains: a C-terminal epoxide hydrolase domain and an N-terminal phosphatase domain. Epidemiology and animal studies have attributed a variety of cardiovascular and anti-inflammatory effects to the C-terminal epoxide

[Effect of whole-body vibration on glucose concentration and gluconeogenesis enzyme activity in the blood and tissues of rabbits with experimental hypercholesterolemia].

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Under conditions of experimental hypercholesterolemia vibration caused variable alterations in glucose-6-phosphatase activity and an increase in fructose-1,6-diphosphatase activity in rabbit tissues as well as an increase of glucose content in blood. At the same time, consumption of glucose and

Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas.

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BACKGROUND Lipid accumulation in the liver and pancreas is primarily caused by combined hyperlipidemia. However, the effect of isolated hypercholesterolemia without hypertriglyceridemia is not fully described. Therefore, our aim was to investigate whether hypercholesterolemia alone leads to

Hypercholesterolemia and hypertriglyceridemia as risk factors of liver dysfunction in children with inflammation receiving total parenteral nutrition.

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OBJECTIVE Hepatic dysfunction, due to parenteral nutrition, may become severe and lead to cirrhosis and hepatic failure, especially in newborns and infants. This study aimed to evaluate the association between the exclusive use of total parenteral nutrition (TPN) and changes in the hepatic profile,

[Lovastatin: short-term treatment of hypercholesterolemia; multicenter clinical trial].

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Two hundred and ten patients (119 men and 91 women, mean age 54) with primary hypercholesterolemia (97% with total serum cholesterol greater than 240 mg/dl) were treated with lovastatin during 12 weeks in a placebo-controlled multicenter trial (10 cities and 21 investigators). All patients remained

Effects of CS-514 on serum lipoprotein lipid and apolipoprotein levels in patients with familial hypercholesterolemia.

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Effects of CS-514, a new competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on serum lipoprotein lipid and apolipoprotein levels were studied in 13 heterozygous patients with familial hypercholesterolemia. Treatment with 10 mg of CS-514 twice daily reduced total serum

Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia.

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BACKGROUND This study addressed the effects of apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, on hepatic oxidative burden and liver injury during diet-induced hypercholesterolaemia. RESULTS Male Wistar rats were fed a 4% cholesterol-enriched diet for 3 weeks.

[Determination of the serum enzyme and dehydrogenase activity of circulating lymphocytes during hemosorption in dietary hypercholesterolemia].

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Hypercholesterolemia, produced in rabbits after long-term feeding with cholesterol, was accompanied by an increase in activity of alkaline phosphatase and LDH in blood serum as well as by a decrease in activity of intracellular dehydrogenases of lymphocytes. After hemosorption content of cholesterol

Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol-lowering effect in patients with type 2 diabetes and hypercholesterolemia.

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OBJECTIVE Accumulating evidence suggests that statins might positively affect bone metabolism. In the present study, we compared the effect of rosuvastatin with that of ezetimibe on bone turnover markers in patients with type 2 diabetes mellitus as well as hypercholesterolemia. METHODS A total of 36

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