Provided are compounds of general formula A and A', wherein X.sub.1 and X.sub.2 are each C, CH or N; R.sub.3 and R.sub.4 are each H, optionally substituted C.sub.1-C.sub.30 saturated or unsaturated chemical group, or together form an optionally substituted C.sub.5-C.sub.8 cycle; Z.sub.1; Z.sub.2 and Z.sub.3 are each N or CH; V is C.dbd.O, C.dbd.S or CH.sub.2; n is from 1 to 12; W.sub.1 and W.sub.2 are each H, CH.sub.2, O or S; and R.sub.1 and R.sub.2 are each H, Cr.sub.1C.sub.6 alkyl, C.sub.1C.sub.6 aryl, C.sub.1C.sub.12 alkylaryl, optionally substituted phenyl, C.sub.1C.sub.6 alkoxy, C.sub.1C.sub.6 thioalkoxy, F, Cl, Br or I. These compounds inhibit steroid sulfatase (STS), act as selective estrogen receptor modulators (SERMs), increase alkaline phosphatase (ALP) activity, and are useful in the treatment of medical conditions involving hormones such as breast cancer, prostate cancer, endometriosis, osteoporosis, benign prostatic hyperplasia and endometrial cancer. ##STR00001##

hyperplasia/phosphatase

Substituted 1,2,3,4-tetrahydroisoquinoline derivatives for the treatment of hormone-dependent diseases

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