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inflammation/diarrea
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Materials and methods for prevention and treatment of diarrhea and inflammation in the gastrointestinal tract
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BACKGROUND OF INVENTION
Diarrhea is a common illness affecting people of all ages. The loss of fluids through diarrhea can cause dehydration and electrolyte disturbances.
In the United Sates, adults have an average of one episode of acute diarrhea each year; diarrhea occurs more frequently in
Composition and method for reducing diarrhea in a mammal
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BACKGROUND OF THE INVENTION
Maintaining the well being of the GI tract of a mammal is a very desirable goal. Particularly annoying are inflammatory conditions of the GI tract. Some of the signs of inflammation of the GI tract include acute or chronic diarrhea, soft stools, blood in stool, vomiting,
Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
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BACKGROUND OF THE INVENTION
EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-
5-ASA derivatives having anti-inflammatory and antibiotic activity and methods of treating diseases therewith
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FIELD OF THE INVENTION
The present invention relates to 5-ASA derivatives and methods of treating diseases therewith.
BACKGROUND OF THE INVENTION
Many people suffer from inflammatory bowel disease (IBD). TRD is a generic term used to refer to two inflammatory diseases, ulcerative colitis and Crohn's
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors
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This application is a .sctn. 371 of International Application No. PCT/IB2015/056905, filed 9 Sep. 2015, which claims the priority of PCT/CN2015/086995, filed 14 Aug. 2015, and PCT/CN2014/086197, filed 10 Sep. 2014, which are incorporated herein in their entireties.
FIELD OF INVENTION
This invention
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Compounds as rearranged during transfection (RET) inhibitors
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This application is a .sctn.371 of International Application No. PCT/CN2015/089332, filed 10 Sep. 2015, which claims the priority of PCT/CN2014/000834, filed 10 Sep. 2014, which are incorporated herein in their entireties.
FIELD OF INVENTION
This invention relates to novel compounds which are
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Compounds as rearranged during transfection (RET) inhibitors
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FIELD OF INVENTION
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of
Pyridine derivatives as rearranged during transfection (RET) kinase inhibitors
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This application is a 371 of International Application No. PCT/IB2014/059817, filed 14 Mar. 2014, which claims priority of PCT/CN2014/072449, filed 24 Feb. 2014; PCT/CN2013/090059, filed 20 Dec. 2013; and PCT/CN2013/072683, filed 15 Mar. 2013.
FIELD OF INVENTION
This invention relates to novel
Vanilloid receptor ligands and their use in treatments
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BACKGROUND
The vanilloid receptor 1 (VR1) is the molecular target of capsaicin, the active ingredient in hot peppers. Julius et al. reported the molecular cloning of VR1 (Caterina et al., 1997). VR1 is a non-selective cation channel which is activated or sensitized by a series of different stimuli
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