inflammation/tyrosine

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Inhibition of Bruton's tyrosine kinase (Btk) in the lung to treat severe lung inflammation and lung injury

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BACKGROUND OF THE INVENTION Field of the Invention The invention in the field of biochemistry, molecular biology and medicine relates to the treatment of severe lung inflammation and acute lung injury (ALI) by inhibition of Bruton's tyrosine kinase (Btk) in the lung using small inhibitory RNA

RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions

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FIELD OF THE INVENTION The present invention relates to the field of interfering RNA compositions for silencing spleen tyrosine kinase (Syk) and for treatment of a Syk-related inflammatory condition. Such conditions include allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma,

RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions

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RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions

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Use of tyrosine kinase inhibitors for treating inflammatory diseases

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The present invention relates to a method for treating inflammatory diseases such as rheumatoid arthritis (RA), comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor

Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation

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TECHNICAL FIELD OF THE INVENTION The present invention relates to methods for the prophylactic and therapeutic treatment of retinal ischemia and ocular inflammation. BACKGROUND OF THE INVENTION Retinal ischemia occurs as a result of occlusion of a retinal blood vessel, such as occlusion of the

Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)

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The present invention relates to a method for treating inflammatory bowel diseases (IBD), such as crohn's disease, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said

Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same

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CROSS REFERENCE TO RELATED APPLICATION This application is a U.S. national stage application of PCT/KR2011/003873 filed May 26, 2011 and claims the foreign priority benefit of International Patent Application No. PCT/KR2010/003332, filed on May 26, 2010, and Korean Application No. 10-2010-0049368,

Use of sesquiterpene lactones for treatment of severe inflammatory disorders

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This invention pertains to sesquiterpene lactones and sesquiterpene lactone-containing plant extracts and preparations for pharmaceutical uses, particularly the use of sesquiterpene lactones for the treatment of severe inflammatory disorders, for example, sepsis, septic shock, or septicemia. A large

Aminotriazolopyridine for use in the treatment of inflammation, and pharmaceutical compositions thereof

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FIELD OF THE INVENTION The present invention relates to the medical use of a compound of the invention according to Formula I. In particular the present invention relates to the use of a compound of the invention according to Formula I for the treatment of inflammatory conditions, autoimmune

Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48

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FIELD OF THE INVENTION This invention relates to a method of inhibiting Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al., Proc.

Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

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The present invention relates to a series of substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to bioisosteres of quinoline and quinazoline derivatives which exhibit protein

6-(2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazin-7-yl)-N-(4-morpholinophenyl)im- idazo[1,2-a] pyrazin-8-amine as a spleen tyrosine kinase inhibitor

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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Not Applicable. THE NAMES OF PARTIES TO A JOINT RESEARCH AGREEMENT Not Applicable INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC Not Applicable BACKGROUND OF THE INVENTION (1) Field of the Invention (2) Description

Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds

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FIELD OF INVENTION Certain imidazo[1,2-a]pyrazin-8-ylamine and related compounds, which when appropriately substituted are inhibitors of tyrosine kinase activity, including Bruton's tyrosine kinase (Btk) activity, are provided herein. Certain compounds provided herein are highly active and/or

Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases

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FIELD OF THE INVENTION This invention relates to novel pyrrolopyridazine compounds that are useful as inhibitors of Janus kinases (JAKs), more particularly JAK3. This invention also relates to a method of using the compounds in the treatment of inflammatory and autoimmune diseases, and to

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