Ivermectin

Onchocerciasis

Epilepsy

Effect of Ivermectin on frequency of seizures

Centre de Recherche en Maladies Tropicales de l'Ituri

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy: A Randomized Clinical Trial

>50 % reduction in seizure frequency compared to baseline

Robert Colebunders

Professor infectious diseases

115 participants will be randomized to oral Doxycycline 100 mg daily for six weeks.
Each capsule contains doxycycline hyclate equivalent to 100 mg of doxycycline base.
Treatment will be initiated in hospital but will be continued at home.
Scheduled study clinic and home visits will be conducted at 6, 12, 24 months and at 2, 4 and 6 weeks respectively for adherence monitoring and assessment of safety.

115 participants will be randomized to the placebo arm for matching capsules containing no active ingredients daily for six weeks.
Placebo will be initiated in hospital but will be continued at home.
Scheduled study clinic and home visits will be conducted at 6, 12, 24 months and at 2, 4 and 6 weeks respectively for adherence monitoring and assessment of safety.

Seizures

115 participants will be randomized to either oral Doxycycline 100 mg daily for six weeks.
Treatment will be initiated in hospital but will be continued at home.
Scheduled study clinic visits will be made by the participants at 6, 12 and 24 months.
Each participant will be visited at home at 2, 4 and 6 weeks for adherence monitoring and assessment of safety

Doxycycline

- Placebo (matching capsules containing no active ingredients)

Placebo

Makerere University College of Health Sciences

Doxycycline for the Treatment of Nodding Syndrome

Doxycycline for the Treatment of Nodding Syndrome: A Phase II, Randomised Placebo Controlled Trial

College of Health Sciences

Senior Lecturer

Makerere University

University of Oxford

In this group patients receive volemic standard treatment (conventional)

In this group patients receive volemic small treatment (restrictive)

Acute Abdomen

Goals:
arterial pressure mean ≥ 65 mmHg or equal to the pre-operative
diuretic rhythm ≥ 1 ml / Kg / h
venous saturation in vena cava ≥ 70% or mixed venous saturation as Swan Ganz's catheter (SG) ≥ 65%
BE> - 3
Central Venous Pression (PVC) ≥ 8 mmHg; for patients undergoing mechanical ventilation, this limit may be raised to 12-15 mmHg.

Standard fluidic resuscitation.

Goals of the treatment:
arterial pressure mean ≥ 60 mmHg or ≥ 10% less than the preoperative values
diuretic rhythm ≥ 0.5 ml / kg / h
venous saturation in vena cava ≥ 60% or mixed venous saturation ≥ 55% by SG
BE> - 5
PVC goal not necessary
To achieve the therapeutic goals set out above will be executed a volemic fill up to values of PVC ≤ 5 mmHg or at maximum values of 2 mmHg more the incoming If after proper filling the targets aren't yet achieved, the patient will begin infusion of vasoactive drugs following the practice of department. If after 12 hours of admission the water balance will be > 10-15 ml / kg / h an infusion of furosemide should be initiated

Volemic small treatment

Different Fluidic Strategy in Patients With Acute Abdomen : The Sure Volume

MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study

The purpose of this work is to evaluate the clinical changes determined by a different volemic strategy.

Emanuela Biagioni

Azienda Ospedaliero-Universitaria di Modena

Oral pyridoxine, 30- 50 mg/kg/day in one daily dose (powder form)for a period of four weeks followed by cross-over to Phenytoin arm for another four weeks

Phenytoin Oral, 5 mg/kg/day in two equally divided doses(powder form)for a period of four weeks and then cross-over to Pyridoxine arm for another four weeks

Sodium valproate oral, 10 - 15 mg/kg/day once daily powder form)for a period of four weeks and then cross-over to placebo arm for another four weeks

Placebo will consist of an inert substance (e.g., gelatin) with an appearance similar to medication in similar dosage as the study arms for a period of 4 weeks and subsequent cross-over to Sodium Valproate arm

Nodding Syndrome

Pyridoxine

Sodium Valproate

Phenytoin

Kitgum Nodding Syndrome Treatment Center, Kitgum General Hospital

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

Change (Reduction) in frequency of observed head nodding or other seizure activity episodes among children with NS

intestinal volvulus/ataque epiléptico

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy

Doxycycline for the Treatment of Nodding Syndrome

Different Fluidic Strategy in Patients With Acute Abdomen : The Sure Volume

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

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