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ischemia/tyrosine

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14 resultados

Methods for treating ischemia-reperfusion injury

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BACKGROUND OF THE INVENTION In general, the invention is related to methods for treating, ameliorating, or attenuating an ischemia-reperfusion injury. Ischemia-reperfusion (I/R) injury represents a leading cause of morbidity and mortality and is a major clinical problem. Reperfusion of tissues and

Tyrosine kinase inhibitors

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BACKGROUND OF THE INVENTION The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis,

Polymorphs with tyrosine kinase activity

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BACKGROUND OF THE INVENTION The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxyl ic acid methylamide, which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these polymorphs,

Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors

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BACKGROUND OF THE INVENTION The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis,

Heterocyclic compounds useful as inhibitors of tyrosine kinases

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FIELD OF THE INVENTION This invention relates to substituted compounds of formula (I): ##STR2## wherein Ar.sub.1, X, Y, P, Q and Het are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell

Heterocyclic compounds useful as inhibitors of tyrosine kinases

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FIELD OF THE INVENTION This invention relates to substituted compounds of formula (I): ##STR2## wherein Ar.sub.1, X, Y, P, Q and Het are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell

Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation

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TECHNICAL FIELD OF THE INVENTION The present invention relates to methods for the prophylactic and therapeutic treatment of retinal ischemia and ocular inflammation. BACKGROUND OF THE INVENTION Retinal ischemia occurs as a result of occlusion of a retinal blood vessel, such as occlusion of the

Heterocyclic compounds useful as inhibitors of tyrosine kinases

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TECHNICAL FIELD OF THE INVENTION This invention relates to substituted compounds of formula (I): ##STR2## wherein Ar.sub.1, R.sub.a, R.sub.4, R.sub.5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting

Heterocyclic compounds useful as inhibitors of tyrosine kinases

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TECHNICAL FIELD OF THE INVENTION This invention relates to substituted compounds of formula (I): ##STR2## wherein Ar.sub.1, R.sub.a, R.sub.4, R.sub.5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting

Method for diagnosing and monitoring cardiac ischemia in patients with acute chest pain and without myocardial infarction

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FIELD OF THE DISCLOSURE The present disclosure relates to the field of medical diagnostics. BACKGROUND An aim of modern medicine is to provide personalized or individualized treatment regimens. Those are treatment regimens which take into account a patient's individual needs or risks. A particularly

Tyrosine-derived compounds as calcium channel antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to compounds that act to block calcium channels; methods of using the compounds to treat stroke, cerebral ischemia, pain, head trauma, or epilepsy; and to pharmaceutical compositions that contain the compounds of the

Tyrosine-derived compounds as calcium channel antagonists

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CROSS REFERENCE This application is a 371 of PCT/US99/12276 filed Jun. 2, 1999. BACKGROUND OF THE INVENTION FIELD OF THE INVENTION The present invention relates to compounds that act to block calcium channels; methods of using the compounds to treat stroke, cerebral ischemia, pain, head trauma, or

Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof

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BACKGROUND The present invention is directed to glycosulfopeptides and methods of their use in treating inflammation and disorders related to leukocyte rolling mediated by P-selectin binding. Inflammation is the reaction of vascularized tissue to local injury. This injury can have a variety of

Revascularization cells derived from mononuclear cells, and method of inducing differentiation thereof

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TECHNICAL FIELD The present invention relates to a new revascularization cell population derived from a mononuclear cell population and a method of inducing differentiation thereof. More specifically, the present invention relates to a new revascularization cell population that is derived from
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